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Venous Ulcers of the Lower Limbs Due to Congenital Thalidomide-Related Valve Defect

Section of Dermatology, Department of Clinical Medicine and Immunological Sciences, rubegni{at}unisi.it

Sara Poggiali, MD

Section of Dermatology, Department of Clinical Medicine and Immunological Sciences

Roberta Bilenchi, MD

Section of Dermatology, Department of Clinical Medicine and Immunological Sciences

Agnese Diana, MD

Section of Dermatology, Department of Clinical Medicine and Immunological Sciences

Massimiliano Risulo, MD

Section of Dermatology, Department of Clinical Medicine and Immunological Sciences

Letizia Civeli, MD

Department of Radiology, University of Siena, Policlinico "Le Scotte, Italy

Michele Fimiani, MD

Section of Dermatology, Department of Clinical Medicine and Immunological Sciences

A 44-year-old woman with fetal thalidomide syndrome and congenital pseudoainhum of the left big toe had a 5-year history of painful nonhealing ulcers in the left malleolar region. Venous Doppler ultrasonography showed hypoagenesis of the valve flaps of the deep and superficial venous circuit. To our knowledge, this is the first description of congenital pseudoainhum associated with fetal thalidomide syndrome. The coexistence of cutaneous ulcers in our case might be coincidental but may be related to a congenital valve defect (hypoagenesis) caused by thalidomide.

This version was published on September 1, 2007

Angiology, Vol. 58, No. 4, 491-493 (2007)
DOI: 10.1177/0003319706292013


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