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Angiology, Vol. 58, No. 3, 269-274 (2007)
DOI: 10.1177/0003319707302543

Plasma Levels of B-Type Natriuretic Peptide in Patients With Unstable Angina Pectoris or Acute Myocardial Infarction: Prognostic Significance and Therapeutic Implications

Waqas Ahmed, MD

Department of Cardiology, Shifa International Hospital, Islamabad, Pakistan

Saman Zafar, MBBS

Department of Cardiology, Shifa International Hospital, Islamabad, Pakistan

Ali Y. Alam, MBBS

Department of Cardiology, Shifa International Hospital, Islamabad, Pakistan

Naveed Ahktar, MD

Department of Cardiology, Shifa International Hospital, Islamabad, Pakistan

Mumtaz A. Shah, MBBS

Department of Cardiology, Shifa International Hospital, Islamabad, Pakistan

Martin A. Alpert, MD

Department of Medicine, St. John's Mercy Medical Center, St. Louis, MO, USA, alpema{at}stlo.mercy.net

Plasma B-type natriuretic peptide (BNP) levels were obtained from 146 patients with unstable angina pectoris, non—ST-segment elevation myocardial infarction (MI), or ST-segment elevation MI to determine their value in predicting the presence of new heart failure, recurrent MI or ischemia, or death 1 month after the index event. Patients with elevated plasma BNP levels (>80 pg/mL) had a significantly higher incidence of new heart failure and all-cause mortality than those with a normal plasma BNP level (≤80 pg/mL). Early revascularization with percutaneous intervention or coronary artery bypass grafting significantly reduced the incidence of new heart failure and all-cause mortality in patients with an elevated plasma BNP level, but had no effect on individual outcomes in the normal plasma BNP subgroup.


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