This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (5) Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Giannini, D. Articles by Balbarini, A. Search for Related Content PubMed PubMed Citation Articles by Giannini, D. Articles by Balbarini, A. Pubmed/NCBI databases Substance via MeSH Medline Plus Health Information Secondhand Smoke Social Bookmarking                         What's this?

The Effects of Acute Passive Smoke Exposure on Endothelium-Dependent Brachial Artery Dilation in Healthy Individuals

Angiology University of Pisa

A. Leone, MD

Medicine and Health Division, City Hospital, Massa-Carrara, Italy, reliol{at}libero.it

D. Di Bisceglie, MD

Medicine and Health Division, City Hospital, Massa-Carrara, Italy

M. Nuti, MD

Angiology University of Pisa

G. Strata, MD

Angiology University of Pisa

F. Buttitta, MD

Angiology University of Pisa

L. Masserini, MD

Angiology University of Pisa

A. Balbarini, MD

Angiology University of Pisa

Passive smoking has both short-term and long-term vascular effects. It is not clear whether impairment of endothelial function reflects the acute effects of passive smoke exposure or the chronic effects. The purpose of this study was to assess the hypothesis that short-term exposure to passive smoke impairs endothelium-dependent vasodilation in healthy nonsmokers. Eighteen healthy young never smokers (12 men, 6 women) 21 to 55 years old (mean ± SD: 34 ±9 years) underwent ultrasonography measuring baseline brachial-artery diameter and brachial-artery diameter during hyperemia and after sublingual administration of nitroglycerin, twice: in a smoke-free environment, and then in the same environment polluted by 30 to 35 ppm carbon monoxide. Each subject served as his/her control. Carboxyhemoglobin was measured in blood samples of subjects tested. Mean value of carboxyhemoglobin was 0.6 ±0.5% in a smoke-free environment and 1.4 ± 0.5% in a smoking environment (p <0.02). Mean values of flow-mediated dilation (FMD) were 12.6% ± 7.8% in a smoke-free environment versus 6.8 ± 7.8% in a smoking environment (p <0.01). On the contrary, nitroglycerin-induced vasodilation did not show any statistical difference (21 ± 9.8% versus 23 ±1.4%). Finally, the increase of carboxyhemoglobin was related statistically to the impairment of flow-mediated dilation (r = 0.51; p <0.002). Passive smoking impaired flow-mediated vasodilation in healthy never smokers in a smoking environment. The impairment was strongly related to carboxyhemoglobin level.

Angiology, Vol. 58, No. 2, 211-217 (2007)
DOI: 10.1177/0003319707300361


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				K. I. Paraskevas, V. Stathopoulos, D. P. Mikhailidis, and D. Perrea Smoking, Abdominal Aortic Aneurysms, and Ischemic Heart Disease: Is There a Link? Angiology, January 1, 2009; 59(6): 664 - 666. [PDF]

				K. I. Paraskevas, T. T. Papas, P. Pavlidis, N. Bessias, and V. Andrikopoulos The Importance of Conservative Measures in Peripheral Arterial Disease: An Update Angiology, October 1, 2008; 59(5): 529 - 533. [PDF]

				E. Anastasakis, K. I. Paraskevas, N. Papantoniou, G. Daskalakis, S. Mesogitis, D. P. Mikhailidis, and A. Antsaklis Association Between Abnormal Uterine Artery Doppler Flow Velocimetry, Risk of Preeclampsia, and Indices of Arterial Structure and Function: A Pilot Study Angiology, August 1, 2008; 59(4): 493 - 499. [Abstract] [PDF]

				K. I. Paraskevas, N. Bessias, T. T. Papas, C. D. Gekas, V. Andrikopoulos, and D. P. Mikhailidis Do Different Vascular Risk Factors Affect All Arteries Equally? Angiology, August 1, 2008; 59(4): 397 - 401. [Abstract] [PDF]