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Microcirculatory Effects of Viatromb® Spray Gel Heparin in Chronic Venous Insufficiency: Evaluation of TcPO₂ and PCO₂—A Product Evaluation Study

Irvine2 Vascular Lab and Physiology, Department of Biomedical Sciences, G. D'Annunzio, Chieti-Pescara University

Gianni Belcaro, MD, PhD

Irvine2 Vascular Lab and Physiology, Department of Biomedical Sciences, G. D'Annunzio, Chieti-Pescara University, cardres{at}abol.it

Silvia Errichi, MD

Irvine2 Vascular Lab and Physiology, Department of Biomedical Sciences, G. D'Annunzio, Chieti-Pescara University

Luciano Pellegrini, MD

Irvine2 Vascular Lab and Physiology, Department of Biomedical Sciences, G. D'Annunzio, Chieti-Pescara University

Andrea Ledda, MD

Irvine2 Vascular Lab and Physiology, Department of Biomedical Sciences, G. D'Annunzio, Chieti-Pescara University

Giulia Vinciguerra, PhD

San Valentino Vascular Screening Project, and Faculty of Motory Sciences, L'Aquila University (GV), Italy

Andrea Ricci, MD

Irvine2 Vascular Lab and Physiology, Department of Biomedical Sciences, G. D'Annunzio, Chieti-Pescara University

Giuseppe Gizzi, MD

Irvine2 Vascular Lab and Physiology, Department of Biomedical Sciences, G. D'Annunzio, Chieti-Pescara University

Edmondo Ippolito, MD

Irvine2 Vascular Lab and Physiology, Department of Biomedical Sciences, G. D'Annunzio, Chieti-Pescara University

Filiberto Fano, MD

Irvine2 Vascular Lab and Physiology, Department of Biomedical Sciences, G. D'Annunzio, Chieti-Pescara University

Mark Dugall, MD

Irvine2 Vascular Lab and Physiology, Department of Biomedical Sciences, G. D'Annunzio, Chieti-Pescara University

Giovanni Acerbi, MD

Irvine2 Vascular Lab and Physiology, Department of Biomedical Sciences, G. D'Annunzio, Chieti-Pescara University

Marisa Cacchio, MD

Irvine2 Vascular Lab and Physiology, Department of Biomedical Sciences, G. D'Annunzio, Chieti-Pescara University

Andrea Di Renzo, BA

Irvine2 Vascular Lab and Physiology, Department of Biomedical Sciences, G. D'Annunzio, Chieti-Pescara University

Morio Hosoi, MD

Irvine2 Vascular Lab and Physiology, Department of Biomedical Sciences, G. D'Annunzio, Chieti-Pescara University

Stefano Stuard, MD

Irvine2 Vascular Lab and Physiology, Department of Biomedical Sciences, G. D'Annunzio, Chieti-Pescara University

Marcello Corsi, MD

Irvine2 Vascular Lab and Physiology, Department of Biomedical Sciences, G. D'Annunzio, Chieti-Pescara University

The evolution of microcirculatory methods and the definition of the concept of venous microangiopathy allow the study in a quantitative way of microcirculatory changes produced by pharmacologic treatments at the areas most frequently and severely affected by chronic venous insufficiency (CVI), venous hypertensive microangiopathy, and venous ulcerations. This pilot study compares subjects with CVI, in the area most affected by venous hypertension in a 2-week registry. Elastic compression, compression plus Viatromb^® (lyposomal spray gel heparin), Lioton^® (gel including heparin), and Viatromb^® alone were compared. Subjects were evaluated for laser Doppler flux, transcutaneous partial pressure of oxygen (TcPO2), and partial pressure of carbon dioxide (PCO2) and CVI analogic symptom scale. In the Viatromb^® groups (B and D), significant decreases in laser Doppler flux, PCO2, and CVI score were observed. The decrease was proportionally more important in the elastic compression plus Viatromb ^® group. Partial pressure of oxygen (PO2) was significantly increased. No significant changes were observed in the Lioton^® group. There was a good effect for compression only. These differences are significant, as they can be observed even in small groups (10-15 patients). No treatment side effects were observed, and compliance and tolerability were very good.

Key Words: venous disease • varicose veins • lipodermatosclerosis • elastic compression • edema • veins • venous microangiopathy

Angiology, Vol. 58, No. 1S, 21S-26S (2007)
DOI: 10.1177/0003319706297625


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