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Effects of Heart Rate on Brachial-Ankle Pulse Wave Velocity and Ankle-Brachial Pressure Index in Patients Without Significant Organic Heart Disease

Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China

Kun-Tai Lee, MD

Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China

Chih-Sheng Chu, MD

Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China

Ming-Yi Lee, MD

Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China

Tsung-Hsien Lin, MD

Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China

Wen-Chol Voon, MD

Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China

Sheng-Hsiung Sheu, MD

Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China

Wen-Ter Lai, MD

Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China, cobe.shm{at}msa.hinet.net

This study evaluated the effects of heart rate (HR) on brachial-ankle pulse wave velocity (baPWV) and ankle-brachial pressure index (ABI). Thirty-two patients without significant organic heart disease underwent elective cardiac catheterization or electrophysiologic study, and were then enrolled in right atrial pacing (RAP; 11 men, 9 women; aged 48 15 years) or right ventricular pacing (RVP; 6 men, 6 women, aged 45 13 years) studies. Three different HR levels (90, 100, and 110 beats per minute) were paced in random order. By stepwise, multiple linear regression analysis, age, systolic blood pressure (SBP), and pulse pressure (PP) correlated positively with baseline baPWV. In the RAP group, as HR increased, baPWV and left brachial diastolic blood pressure increased significantly (p 0.015), while ABI, left ankle SBP, left brachial PP, and left ankle PP decreased significantly (p 0.013). In the RVP group, as HR increased, baPWV also increased significantly (p=0.001), while ABI, left ankle SBP, and PP decreased significantly (p 0.034). Values of baPWV and ABI may be influenced by HR in young and middle-aged patients without significant organic heart disease. When these values are used to evaluate and follow up cardiovascular risk in patients, HR changes should be considered.

Angiology, Vol. 58, No. 1, 67-74 (2007)
DOI: 10.1177/0003319706295481


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