This Article Free Full Text (Free PDF) Free References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Aguiar, T. Articles by Bouskela, E. Search for Related Content PubMed PubMed Citation Articles by Aguiar, T. Articles by Bouskela, E. Social Bookmarking                   What's this?

Nailfold Videocapillaroscopy in Primary Sjögren’s Syndrome

Laboratory for Research in Microcirculation, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil

Eliane Furtado, BSc

Laboratory for Research in Microcirculation, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil

David Dorigo, PhD

Laboratory for Research in Microcirculation, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil

Daniel Bottino, MD, PhD

Laboratory for Research in Microcirculation, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil, dbottino1{at}yahoo.com.br

Eliete Bouskela, MD, PhD, FACA

Laboratory for Research in Microcirculation, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil

Nailfold videocapillaroscopy was performed in 2 groups of subjects: 14 healthy volunteers (C) and 15 patients with primary Sjögren’s syndrome (PSS). This was a controlled clinical trial, matched by age and sex. The aims of this study were to evaluate (1) functional capillary density (number of capillaries with flowing red blood cells per mm², FCD); (2) capillary red blood cell velocity at rest (RBV), maximum capillary red blood cell velocity (RBV_max) after 1 minute ischemia, and the time to reach it (TRBV_max), taking into account the presence or absence of Raynaud’s phenomenon (RP) in the analysis; (3) nailfold capillary morphology; and (4) afferent (AFD), apical (APD), and efferent (EFD) capillary diameters. The mean values obtained for controls versus patients, respectively, were (mean ± SD): FCD (per mm²) 8.0 ±1.6 and 10.1 ±3.6; RBV (mm/s) 0.9 ±0.4 and 0.7 ±0.2; RBV_max (mm/s) 1.7 ±0.9 and 1.3 ±0.3; TRBV_max (s) 4.5 ±0.8 and 5.8 ±1.6 (p=0.02); and TRBV_max (s) in patients with RP=6.7 ±1.6 and without RP=5.6 ±1.6 (p=0.52). The correlation between RBV and RBV_max for each group, using the Pearson’s coefficient, was significant only for the control group (p=0.007), estimated correlation coefficient = 0.68. Controls and patients showed, in the majority of fields examined, normal morphologic patterns of capillaries. The capillary diameters were AFD (µm) 10.8 ±1.5 and 11.3 ±1.8; APD (µm) 16.3 ±2.4 and 16.8 ±2.9; and EFD (µm) 12.3 ±1.4 and 13.7 ±1.9. These results indicate that these patients have longer time to reach RBV_max, suggesting an impairment of the reactive hyperemia response, which could correlate with clinical features of the disease, ie, abnormal macrovascular and microvascular reactivity.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?