This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Miyawaki, K. Articles by Matsubara, H. Search for Related Content PubMed PubMed Citation Articles by Miyawaki, K. Articles by Matsubara, H. Social Bookmarking                         What's this?

Beneficial Effect of Gabexate Mesilate on Microscopic Polyangiitis With Renal Dysfunction and Pulmonary Hemorrhage

A Case Report

Department of Cardiology, Kyoto Prefectural Rakuto Hospital, Kyoto, Japan

Jun Shiraishi, MD

Department of Cardiology, Kyoto Prefectural Rakuto Hospital, Kyoto, Japan; Department of Cardiology, Kyoto First Red Cross Hospital, Honn-machi 15-749, Higashiyama-ku, Kyoto 605-0981, Japan; sjun{at}msj.biglobe.ne.jp

Yasuhiko Tsutsumi, MD

Emi Shiraishi, MD

Katsuichi Ohtsuki, MD

Miho Inoue, MD

Department of Cardiology, Kyoto Prefectural Rakuto Hospital, Kyoto, Japan

Tetsuya Tatsumi, MD

Akihiro Azuma, MD

Hiroaki Matsubara, MD

Department of Cardiology and Vascular Regenerative Medicine, Kyoto Prefectural University School of Medicine, Kyoto, Japan

Corticosteroids and cyclophosphamide are the mainstay of the treatment of microscopic polyangiitis involving pulmonary hemorrhage or rapidly progressive glomerulonephritis. However, patients with advanced age are unable to tolerate this combined therapy, because of a relatively high incidence of side effects including infection, hemorrhagic cystitis, and bone marrow suppression. The authors encountered an 80-year-old patient with pulmonary hemorrhage and renal dysfunction ascribed to microscopic polyangiitis and achieved successful treatment by employing gabexate mesilate in addition to corticosteroids. The present case suggests that gabexate mesilate may be a therapeutic option for microscopic polyangiitis with progressive renal failure and pulmonary hemorrhage.

Angiology, Vol. 57, No. 4, 522-525 (2006)
DOI: 10.1177/0003319706290736


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?