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Angiology
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Factor V Leiden Mutation in Venous Thrombosis in Southeast Turkey

Sevgi Kalkanli, PhD

Department of Medical Genetic-Biology, University of Dicle, Diyarbakir, Turkey, sgkalkanli{at}yahoo.com

Orhan Ayyildiz, MD

Department of Hematology-Oncology, University of Dicle, Diyarbakir, Turkey

Naci Tiftik, MD

Department of Hematology-Oncology, University of Dicle, Diyarbakir, Turkey

Sabri Batun, PhD

Department of Hematology-Oncology, University of Dicle, Diyarbakir, Turkey

Abdurrahman Isikdogan, MD

Department of Hematology-Oncology, University of Dicle, Diyarbakir, Turkey

Hakan Ince, PhD

Department of Medical Genetic-Biology, University of Dicle, Diyarbakir, Turkey

Selahaddin Tekes, PhD

Department of Medical Genetic-Biology, University of Dicle, Diyarbakir, Turkey

Ekrem Muftuoglu, MD

Department of Hematology-Oncology, University of Dicle, Diyarbakir, Turkey

Venous thrombosis (VT) is a common disease, with an annual incidence in the general population of approximately 1 per 1,000. Factor V Leiden mutation (G1691A) (FVL) is the most common risk factor in venous thrombosis. The prevalence of FVL for thrombosis varies greatly in different regions of the world. FVL mutation has been identified both by conventional method and fluorescence resonance energy transfer (FRET) with the LightCycler. Sixty-one patients with VT, different in age and sex, were consecutively entered into this study to assess the prevalence of FVL in VT in southeast Turkey. FVL mutation was found in 24.6% (15/61). Fourteen individuals were heterozygous and 1 homozygous, a rate of 22.9% and 1.6%, respectively. In conclusion, the authors suggest that FVL mutation is common in patients with venous thrombosis in southeast Turkey.

Angiology, Vol. 57, No. 2, 193-196 (2006)
DOI: 10.1177/000331970605700209
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