This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (24) Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Alnaeb, M. E. Articles by Hamilton, G. Search for Related Content PubMed PubMed Citation Articles by Alnaeb, M. E. Articles by Hamilton, G. Social Bookmarking                         What's this?

Short-term Lipid-Lowering Treatment with Atorvastatin Improves Renal Function But Not Renal Blood Flow Indices in Patients with Peripheral Arterial Disease

University Department of Surgery, Royal Free Hospital NHS Trust and Royal Free and University College Medical School, University College London, London, UK

F. Youssef, FRCS

University Department of Surgery, Royal Free Hospital NHS Trust and Royal Free and University College Medical School, University College London, London, UK

D. P. Mikhailidis, MD, FASA, FRCP, FRCPath

University Departments of Surgery and Clinical Biochemistry, Royal Free Hospital NHS Trust and Royal Free and University College Medical School, University College London, London, UK, mikhailidis{at}aol.com

G. Hamilton, MD, FRCS

University Department of Surgery, Royal Free Hospital NHS Trust and Royal Free and University College Medical School, University College London, London, UK

Some studies have suggested that lipid lowering with statins exerts favorable effects on the progression of chronic kidney disease. Therefore, the authors assessed the effects of short-term atorvastatin treatment on biochemical markers of renal function and evaluated duplex indices of renal blood flow (RBF) in patients with peripheral arterial disease. Hyperlipidemic claudicants (n=18), aged 44-85 years, were treated for 8 weeks with 20 mg/day atorvastatin. Blood tests at baseline and after 8 weeks included serum fasting lipids, creatinine, urate, and cystatin C (a sensitive indicator of renal function) levels. RBF was also assessed (n=9) by measuring pulsatile and resistance duplex indices. As expected, there was a significant improvement in total cholesterol, low-density lipoprotein cholesterol, and triglycerides. There was also a significant (p<0.0001) fall in serum creatinine from 89 (58-125) to 79 µmol/L (54-119) and an increase in calculated creatinine clearance (CrCl) from 72 (40-129) to 80 mL/minute (47-138; p<0.0001). Serum cystatin C values decreased significantly (p=0.0002) from 1.04 (0.57-1.56) to 0.90 mg/L (0.47-1.47). There were no detectable changes in the RBF duplex indices. Treatment of stable claudicants with atorvastatin for 8 weeks was associated with improved renal function (as assessed by serum creatinine, cystatin C, and calculated CrCl) without changes in RBF. Further studies are required to identify the mechanisms involved in this phenomenon.

Angiology, Vol. 57, No. 1, 65-71 (2006)
DOI: 10.1177/000331970605700109


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				J.-H. Liu, C.-C. Chang, S.-M. Wang, C.-Y. Chou, Y.-F. Yang, Y.-L. Liu, H.-H. Lin, and C.-C. Huang Peripheral Arterial Disease and Clinical Risks in Taiwanese Hemodialysis Patients Angiology, February 1, 2010; 61(1): 66 - 73. [Abstract] [PDF]

				A. Karagiannis, K. Tziomalos, P. Anagnostis, T. Gossios, and V. G. Athyros Atherosclerotic Renal Artery Stenosis: Medical Therapy Alone or in Combination With Revascularization? Angiology, August 1, 2009; 60(4): 397 - 402. [PDF]

				R. H. Samson Author Response Vascular and Endovascular Surgery, January 1, 2009; 42(6): 621 - 621. [PDF]

				K. I. Paraskevas, N. Bessias, J. Tzorbatzoglou, D. P. Mikhailidis, and V. Andrikopoulos Effect of Statins on Renal Function in Patients With Peripheral Arterial Disease Vascular and Endovascular Surgery, January 1, 2009; 42(6): 620 - 621. [PDF]

				K. I. Paraskevas, T. T. Papas, P. Pavlidis, N. Bessias, and V. Andrikopoulos The Importance of Conservative Measures in Peripheral Arterial Disease: An Update Angiology, October 1, 2008; 59(5): 529 - 533. [PDF]

				M. E. Alnaeb, V. P. Crabtree, A. Boutin, D. P. Mikhailidis, A. M. Seifalian, and G. Hamilton Prospective Assessment of Lower-Extremity Peripheral Arterial Disease in Diabetic Patients Using a Novel Automated Optical Device Angiology, November 1, 2007; 58(5): 579 - 585. [Abstract] [PDF]

				E. Papalambros, F. Sigala, S. Georgopoulos, K. I. Paraskevas, I. Andreadou, X. Menenakos, P. Sigalas, A. L. Papalambros, G. Vourliotakis, A. Giannopoulos, et al. Malondialdehyde as an Indicator of Oxidative Stress During Abdominal Aortic Aneurysm Repair Angiology, September 1, 2007; 58(4): 477 - 482. [Abstract] [PDF]

				K. I. Paraskevas, G. Hamilton, D. P. Mikhailidis, and C. D. Liapis Letter to the Editor Vascular and Endovascular Surgery, February 1, 2007; 41(1): 87 - 87. [PDF]

				V. G. Athyros, D. P. Mikhailidis, E. N. Liberopoulos, A. I. Kakafika, A. Karagiannis, A. A. Papageorgiou, K. Tziomalos, E. S. Ganotakis, and M. Elisaf Effect of statin treatment on renal function and serum uric acid levels and their relation to vascular events in patients with coronary heart disease and metabolic syndrome: A subgroup analysis of the GREek Atorvastatin and Coronary heart disease Evaluation (GREACE) Study Nephrol. Dial. Transplant., January 1, 2007; 22(1): 118 - 127. [Abstract] [Full Text] [PDF]