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Continuous Intravenous Administration of a Low Dose of Epoprostenol Greatly Decreased Serum Concentrations of Endothelin-1 in Primary Pulmonary Hypertension

A Case Report

Department of Cardiovascular Control, Kochi Medical School, Kochi, and Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan, kakinuma{at}kochi-ms.ac.jp

Satoshi Honma, MD, PhD

Department of Cardiovascular Control, Kochi Medical School, Kochi, and Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan

Takashi Morimoto, MD

Department of Cardiovascular Control, Kochi Medical School, Kochi, and Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan

Hidekazu Maruyama, MD

Department of Cardiovascular Control, Kochi Medical School, Kochi, and Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan

Akira Yamazaki, MD

Department of Cardiovascular Control, Kochi Medical School, Kochi, and Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan

Toshiyuki Ishimitsu, MD, PhD

Department of Cardiovascular Control, Kochi Medical School, Kochi, and Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan

Iwao Yamaguchi, MD, PhD

Department of Cardiovascular Control, Kochi Medical School, Kochi, and Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan

Endothelin-1 (ET-1) is known to be a principal factor in the pathogenesis of primary pulmonary hypertension (PPH). Recently intravenous administration of epoprosterol improved the survival rate in PPH. However, the effect of epoprosterol on ET-1 remains to be investigated. Therefore, we studied a patient with PPH who was treated with a low dose of epoprosterol and examined the serum concentration of ET-1 during the treatment. Epoprosterol greatly decreased the serum concentration of ET-1 in parallel with improvement of the clinical course, suggesting that ET-1 level may be a marker for treatment of PPH.

Angiology, Vol. 56, No. 5, 641-645 (2005)
DOI: 10.1177/000331970505600519


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