This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Web of Science (2) Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Akimoto, T. Articles by Hashimoto, H. Search for Related Content PubMed PubMed Citation Articles by Akimoto, T. Articles by Hashimoto, H. Pubmed/NCBI databases Medline Plus Health Information Lupus Social Bookmarking                         What's this?

Risk Factors for Recurrent Thrombosis: Prospective Study of a Cohort of Japanese Systemic Lupus Erythematosus

Departments of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, takimoto{at}med.juntendo.ac.jp

Shigeto Kobayashi, MD, PhD

Departments of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan

Naoto Tamura, MD, PhD

Departments of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan

Toshiya Ohsawa, PhD

Central Laboratory Medicine, Juntendo University School of Medicine, Tokyo, Japan

Terunaga Kawano, MD, PhD

Departments of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan

Mitsuhiko Tanaka, MD, PhD

Departments of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan

Hiroshi Hashimoto, MD, PhD

Departments of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan

Not only antiphospholipid antibodies (aPLs) but also other factors should be considered in assessing the risk of thrombosis development in patients with systemic lupus erythematosus (SLE) and antiphospholipid antibodies (aPLs). The kinds of risk factors, including past history of thrombotic event (PHTE), hypertension, hypercholesterolemia, diabetes mellitus (DM), obesity, and smoking, in conjunction with aPLs, that contribute to the development of new thrombotic events in patients with SLE and aPLs were studied prospectively over a 5-year observation period. One-hundred and sixty-six Japanese patients with SLE (55 patients with aPLs and 111 patients without aPLs) were examined and followed up for 5 years. Five major risk factors for ischemic coronary disease and stroke according to the Framingham heart cohort study were evaluated objectively in these patients. A significant difference was seen for 4 factors: past history of thrombotic event (PHTE; odds ratio: 101.93; 95% confidence interval: 12.29-845.22; p<0.0001), hypertension (odds ratio: 8.87; 95% CI: 2.58-30.53; p<0.001), DM (odds ratio: 5.42; 95% CI: 1.44-20.46; p<0.05), and lupus anticoagulant (LAC; odds ratio: 47.41; 95% CI: 5.88-382.03, p<0.0001) as aPLs, when the incidence of these risk factors was compared between patients with and without new thrombotic events. Furthermore, PHTE (odds ratio: 30.19, 95% CI: 1.33-683.13), hypertension (odds ratio: 15.44; 95% CI: 1.77-134.80), and LAC (odds ratio: 14.11; 95% CI: 0.48-412.42) showed higher odds ratios than DM (odds ratio: 11.53; 95% CI: 0.83-159.94) on multivariate logistic analysis as well as analysis of the combination of risk factors, suggesting that these are important risk factors for the development of new thrombotic events in patients with SLE and aPLs.

Angiology, Vol. 56, No. 5, 601-609 (2005)
DOI: 10.1177/000331970505600512


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?