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Type III Mixed Cryoglobulinemia Associated with Digital Necrotic Ulcer Successfully Treated with Intermittent Intravenous Pulse Cyclophosphamide

A Case Report

Department of Cardiovascular Surgery, Dicle University of Medicine, Diyarbakir, Turkey, omercak{at}dicle.edu.tr

Orhan Ayyildiz, MD

Department of Hematology, Dicle University of Medicine, Diyarbakir, Turkey

Abdurrahman Isikdogan, MD

Department of Hematology, Dicle University of Medicine, Diyarbakir, Turkey

Cryoglobulinemic vasculitis is an immune complex-mediated vasculitis predominantly affecting small vessels. The authors report an 18-year-old woman with painful digital necrotic ulcer due to type III cryoglobulinemic vasculitis on the basis of systemic lupus erythematosus. Serum protein electrophoresis and immunoelectrophoresis demonstrated a polyclonal peak of the immunoglobulin G (IgG) and IgM type. The patient was successfully treated with intermittent intravenous pulse cyclophosphamide.

Angiology, Vol. 56, No. 4, 489-492 (2005)
DOI: 10.1177/000331970505600418


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