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Lack of Association Between Carotid Intima-Media Thickness and PAF-Acetylhydrolase Mass and Activity in Patients with Primary Hyperlipidemia

Laboratory of Physiology, University of Ioannina, Ioannina, Greece

Sofia Tsouli, MD

Department of Internal Medicine, University of Ioannina, Ioannina, Greece

Evangelia S. Lourida, MSc

Department of Radiology, Medical School, University of Ioannina, Ioannina, Greece

Vasilios Xydis, MD

Laboratory of Biochemistry, Department of Chemistry, University of Ioannina, Ioannina, Greece

Maria I. Argyropoulou, MD

Laboratory of Biochemistry, Department of Chemistry, University of Ioannina, Ioannina, Greece

Moses Elisaf, MD

Department of Internal Medicine, University of Ioannina, Ioannina, Greece

Alexandros D. Tselepis, MD, PhD

Department of Radiology, Medical School, University of Ioannina, Ioannina, Greece, atselep{at}cc.uoi.gr

Carotid intima media thickness (IMT), represents an important clinical indicator of early atherosclerosis. Human plasma platelet-activating factor acetylhydrolase (PAF-AH) is an enzyme primarily associated with low-density lipoprotein (LDL) while a small proportion of enzymatic activity is also associated with high-density lipoprotein (HDL). Plasma paraoxonase 1 (PON1) is an esterase exclusively associated with HDL. The authors investigated the possible relationship between carotid IMT and the plasma levels of PAF-AH mass and activity as well as the PON1 activity in hyperlipidemic patients. One hundred unrelated patients with primary hyperlipidemia and 67 age- and sex-matched normolipidemic apparently healthy volunteers participated in the study. The PAF-AH activity in total plasma and in HDL-rich plasma (HDL-PAF-AH activity), the plasma PAF-AH mass, and the serum PON1 activities toward paraoxon and phenyl acetate were determined. The plasma PAF-AH mass and activity were higher in hyperlipidemic patients compared to controls, whereas the HDL-PAF-AH activity, as well as the serum PON1 activities were not significantly different between the studied groups. When hyperlipidemic patients were divided into 2 subgroups according to their IMT values (IMT <0.7 mm and IMT 0.7 mm) patients with IMT 0.7 mm had significantly higher age, and serum triglyceride concentrations, whereas no difference was found in the plasma PAF-AH mass and activity as well as in the HDL-PAF-AH activity between the 2 studied subgroups. The same phenomenon was observed for serum PON1 activities. In a multivariate analysis, only the age was significantly correlated with IMT values (p<0.05). Neither the total plasma PAF-AH mass and activity nor the HDL-PAF-AH activity are associated with early carotid atherosclerosis.

Angiology, Vol. 56, No. 4, 451-458 (2005)
DOI: 10.1177/000331970505600413


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