This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (9) Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Stakos, D. A. Articles by Boudoulas, H. Search for Related Content PubMed PubMed Citation Articles by Stakos, D. A. Articles by Boudoulas, H. Social Bookmarking                         What's this?

Cardiovascular Effects of Type 1 Diabetes Mellitus in Children

Division of Cardiology, Democritus University of Thrace, Greece

Dara P. Schuster, MD

Division of Endocrinology, The Ohio State University, Columbus, OH

Elizabeth A. Sparks, RN, NP

Division of Cardiology, The Ohio State University, Columbus, OH

Charles F. Wooley, MD

Division of Cardiology, The Ohio State University, Columbus, OH

Kwame Osei, MD

Division of Endocrinology, The Ohio State University, Columbus, OH

Harisios Boudoulas, MD

Center for Clinical Research, Foundation of Biomedical Research, Academy of Athens, Greece, boudoulas{at}bioacademy.gr

Previous studies have shown that type 1 diabetes mellitus (DM) is associated with cardiovascular abnormalities. Early detection and treatment of these abnormalities may help to prevent the natural progression of the disease. The present study was undertaken to define early cardiovascular abnormalities in children with type 1 DM. Simultaneous evaluation of multiple cardiovascular parameters was performed in 14 children with type 1 DM and 14 age- and gender-matched normal subjects. Measurements of carotid artery intima-media thickness (cIMT, echocardiography), carotid and aortic (ascending and abdominal) distensibility (echocardiography, brachial artery blood pressure), aortic pulse wave velocity (carotid to femoral artery, Doppler), and left ventricular dimensions, mass, and function (echocardiography) were performed. Diabetic children demonstrated a greater cIMT (0.36 ±0.04 mm vs 0.31 ±0.03 mm, p=0.002) and decreased carotid artery distensibility (4.4 ±1.6 cm²·dynes^-1·10^-6 vs 6.0 ±1.9 cm²·dynes^-1·10^-6, p<0.01) compared to control. Aortic pulse wave velocity was increased in DM (6.70 ±0.39 vs 6.30 ±0.31, p=0.02) compared to control. Left ventricular diameters, mass, and systolic and diastolic function did not differ between the 2 groups. Simultaneous assessment of multiple cardiovascular parameters in children with type 1 DM revealed impaired carotid artery structure and function, and decreased elastic properties of the aorta, before demonstrable changes in left ventricular structure and function could be detected.

Angiology, Vol. 56, No. 3, 311-317 (2005)
DOI: 10.1177/000331970505600311


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				R. R. Rodriguez, R. A. Gomez-Diaz, J. T. Haj, F. J. A. Garnica, E. R. Soriano, E. N. Meguro, C. A. Aguilar-Salinas, and N. H. Wacher Carotid Intima-Media Thickness in Pediatric Type 1 Diabetic Patients Diabetes Care, October 1, 2007; 30(10): 2599 - 2602. [Abstract] [Full Text] [PDF]

				R. Dalla Pozza, S. Bechtold, W. Bonfig, S. Putzker, R. Kozlik-Feldmann, H. Netz, and H.-P. Schwarz Age of Onset of Type 1 Diabetes in Children and Carotid Intima Medial Thickness J. Clin. Endocrinol. Metab., June 1, 2007; 92(6): 2053 - 2057. [Abstract] [Full Text] [PDF]