This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Masaki, N. Articles by Ohsuzu, F. Search for Related Content PubMed PubMed Citation Articles by Masaki, N. Articles by Ohsuzu, F. Social Bookmarking                         What's this?

Provocation of Microvessel Spasm by Low-Dose Acetylcholine in Patients with Suspected Coronary Artery Disease

Two Case Reports

First Department of Internal Medicine, National Defense Medical College, Saitama, Japan

Bonpei Takase, MD

First Department of Internal Medicine, National Defense Medical College, Saitama, Japan, bonpeit{at}me.ndmc.ac.jp

Kimio Satomura, MD

First Department of Internal Medicine, National Defense Medical College, Saitama, Japan

Takashi Akima, MD

First Department of Internal Medicine, National Defense Medical College, Saitama, Japan

Yoshihiro Matsushima, MD

First Department of Internal Medicine, National Defense Medical College, Saitama, Japan

Haruhiko Hosaka, MD

First Department of Internal Medicine, National Defense Medical College, Saitama, Japan

Akira Hamabe, MD

First Department of Internal Medicine, National Defense Medical College, Saitama, Japan

Akira Kurita, MD

Research Center, National Defense Medical College, Saitama, Japan

Fumitaka Ohsuzu, MD

First Department of Internal Medicine, National Defense Medical College, Saitama, Japan

Endothelial dysfunction plays an important role in the pathogenesis of cardiac syndrome X, and intracoronary low-dose acetylcholine infusion is a widely used diagnostic modality for studying the coronary artery endothelial function. The authors herein report 2 cases of cardiac syndrome X with coronary artery endothelial dysfunction and microvessel spasm. The findings of non invasive testing were positive for ischemia. Coronary angiograms appeared entirely normal in both cases. However, the intracoronary infusion of low-dose (1.5-15 µg/minute) acetylcholine demonstrated an impairment of the coronary blood flow response and consequently provoked an ST-segment elevation in an electrocardiogram. The coronary angiograms showed no spasm in the epicardial arteries. These patients are thus suggested to have cardiac syndrome X with microvessel spasms associated with coronary artery endothelial dysfunction.

Angiology, Vol. 56, No. 2, 211-216 (2005)
DOI: 10.1177/000331970505600211


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?