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Angiology
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Microcirculatory Efficacy of Topical Treatment with Aescin + Essential Phospholipids Gel on Transcutaneous PO2 in Venous Insufficiency

M. R. Cesarone, MD

Irvine2 Vascular Laboratory, Department of Biomedical Sciences, G. D’Annunzio University, Italy

G. Belcaro, MD, PhD

Irvine2 Vascular Laboratory, Department of Biomedical Sciences, G. D’Annunzio University, Italy, cardres{at}pe.abol.it

E. Ippolito, MD

Irvine2 Vascular Laboratory, Department of Biomedical Sciences, G. D’Annunzio University, Italy

A. Ricci, MD

Irvine2 Vascular Laboratory, Department of Biomedical Sciences, G. D’Annunzio University, Italy

M. Ruffini, MD

Irvine2 Vascular Laboratory, Department of Biomedical Sciences, G. D’Annunzio University, Italy

M. Dugall, MD

Irvine2 Vascular Laboratory, Department of Biomedical Sciences, G. D’Annunzio University, Italy

A gel including aescin, essential phospholipids (EPL), and heparin (EG) has been used for many years for local treatment of venous, microcirculatory alterations (varicose veins, chronic venous insufficiency). Bruises, swelling, thrombophlebitis, and contusions are effectively treated with this compound. The aim of this study was the evaluation of the efficacy of the effects of an AEPL (aescin+EPL) gel on the microcirculation in subjects with chronic venous insufficiency, venous hypertension (CVH), and venous microangiopathy. Transcutaneous PO2 was measured at the perimalleolar region. After 2 weeks of treatment, all individual values (100%) were significantly increased (p<0.05). In all patients, PO2 increased, indicating a decrease in level of venous microangiopathy. Considering transcutaneous skin PO2, treatment with AEPL in areas of venous microangiopathy is beneficial in the prevention of ulceration and improves skin healing.

Angiology, Vol. 55, No. 6 suppl, S7-S10 (2004)
DOI: 10.1177/000331970405500602
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This article has been cited by other articles:


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[Abstract] [PDF]


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