This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Belcaro, G. Articles by Dugall, M. Search for Related Content PubMed PubMed Citation Articles by Belcaro, G. Articles by Dugall, M. Social Bookmarking                         What's this?

Microcirculatory Efficacy of Topical Treatment with Aescin + Essential Phospholipids Gel in Venous Insufficiency and Hypertension: New Clinical Observations

Irvine2 Vascular Laboratory, Department of Biomedical Sciences, G. D’Annunzio University, Italy, cardres{at}pe.abol.it

M. R. Cesarone, MD

Irvine2 Vascular Laboratory, Department of Biomedical Sciences, G. D’Annunzio University, Italy

M. Dugall, MD

Irvine2 Vascular Laboratory, Department of Biomedical Sciences, G. D’Annunzio University, Italy

Aescin + essential phospholipids (AEPL) topical gels are used for local treatment of venous and microcirculatory alterations (varicose veins, chronic venous insufficiency). Bruises, swelling, thrombophlebitis, and contusions are effectively treated with AEPL. Active ingredients are escinate and essential phospholipids (EPL). The aim of this new study was the evaluation of the efficacy of the effects of AEPL gel on the microcirculation in subjects with chronic venous insufficiency, venous hypertension (CVH), and venous microangiopathy. Patients were assessed measuring skin flux with laser-Doppler flowmetry (LDF). After 2 weeks of local treatment, all individual values (100%) were significantly decreased (p<0.05), indicating an improvement in the microcirculation. In all treated patients, flux decreased at least 30% (indicating a decrease in the level of venous microangiopathy) (p<0.05). Considering these observations, topical treatment with AEPL in areas of venous microangiopathy is beneficial, can prevent ulceration, and improves the skin healing processes.

Angiology, Vol. 55, No. 6 suppl, S1-S5 (2004)
DOI: 10.1177/000331970405500601


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?