This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Bozkurt, E. Articles by Atesal, S. Search for Related Content PubMed PubMed Citation Articles by Bozkurt, E. Articles by Atesal, S. Social Bookmarking                         What's this?

Plasma Homocysteine Level and the Angiographic Extent of Coronary Artery Disease

Department of Cardiology, Ataturk University, Medical Faculty, Erzurum, Turkey, ebozkurt{at}atauni.edu.tr

Sait Keles, MD

Department of Biochemistry, Ataturk University, Medical Faculty, Erzurum, Turkey

Mahmut Acikel, MD

Department of Cardiology, Ataturk University, Medical Faculty, Erzurum, Turkey

Mesut Islek, MD

Department of Cardiology, Ataturk University, Medical Faculty, Erzurum, Turkey

Sebahattin Ateal, MD

Department of Cardiology, Ataturk University, Medical Faculty, Erzurum, Turkey

Recent epidemiologic studies have shown that moderately elevated plasma homocysteine concentrations are associated with an increased risk for the development of atherosclerotic cardiovascular diseases. But, it is not known whether moderate hyperhomocysteinemia is associated with the angiographic extent of atherosclerotic cardiovascular disease in patients with coronary artery disease (CAD). A possible relationship was investigated between admission plasma homocysteine level and the angiographic extent of coronary artery disease in patients with CAD. In this study, 156 consecutive patients presenting with coronary artery disease (group 1) and control group (group 2) of 35 age-matched persons with normal coronary angiography were enrolled. Blood samples for homocysteine were obtained on admission. Plasma homocysteine concentration was measured with high-performance liquid chromatography with fluorescence detection. Radiographs from coronary angiography were viewed and scored using Sullivan’s method to assess the atherosclerotic involvement of coronary artery disease. There were significant elevations in homocysteine level in group 1 compared to group 2 (15.59 ±5.7 µmol/L, 9.24 ±1.50 µmol/L; respectively, p<0.001). All scores (demonstrated angiographic extension of CAD) correlated significantly with plasma homocysteine levels; however, the Sullivan’s extent score correlated more closely (r =0.68, p<0.001) than both the stenosis score (r =0.44, p<0.01) and vessel score (r =0.35, p<0.05). Elevated homocysteine levels in patients with coronary artery disease correlated with the angiographic extent of atherosclerotic disease.

Angiology, Vol. 55, No. 3, 265-270 (2004)
DOI: 10.1177/000331970405500305


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?