This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Errichi, B. M. Articles by Lania, M. Search for Related Content PubMed PubMed Citation Articles by Errichi, B. M. Articles by Lania, M. Social Bookmarking                         What's this?

Prevention of Recurrent Deep Venous Thrombosis with Sulodexide: The SanVal Registry

General Surgery Osp. Guardiagrele (Ch)

M. R. Cesarone, MD

Department of Biomedical Sciences, Irvine2 Vascular Laboratory, G D’Annunzio University, and San Valentino and Vasto Vascular Screening Project, and St Lucia Clinic, Sulmona

G. Belcaro, MD, PhD

Department of Biomedical Sciences, Irvine2 Vascular Laboratory, G D’Annunzio University, and San Valentino and Vasto Vascular Screening Project, and St Lucia Clinic, Sulmona, cardres{at}pe.abol.it

R. Marinucci, MD

General Surgery Osp. Guardiagrele (Ch)

A. Ricci, MD

Department of Biomedical Sciences, Irvine2 Vascular Laboratory, G D’Annunzio University, and San Valentino and Vasto Vascular Screening Project, and St Lucia Clinic, Sulmona

A. Ippolito, MD

Angiology and Vascular Surgery, University of Milan

R. Brandolini, MD

Department of Biomedical Sciences, Irvine2 Vascular Laboratory, G D’Annunzio University, and San Valentino and Vasto Vascular Screening Project, and St Lucia Clinic, Sulmona

G. Vinciguerra, PhD

Faculty of Motory Sciences, L’Aquila University

M. Dugall, MD

Department of Biomedical Sciences, Irvine2 Vascular Laboratory, G D’Annunzio University, and San Valentino and Vasto Vascular Screening Project, and St Lucia Clinic, Sulmona

A. Felicita, MD

Department of Biomedical Sciences, Irvine2 Vascular Laboratory, G D’Annunzio University, and San Valentino and Vasto Vascular Screening Project, and St Lucia Clinic, Sulmona

L. Pellegrini, MD

Department of Biomedical Sciences, Irvine2 Vascular Laboratory, G D’Annunzio University, and San Valentino and Vasto Vascular Screening Project, and St Lucia Clinic, Sulmona

G. Gizzi, MD

Department of Biomedical Sciences, Irvine2 Vascular Laboratory, G D’Annunzio University, and San Valentino and Vasto Vascular Screening Project, and St Lucia Clinic, Sulmona

M. Ruffini, MD

Department of Biomedical Sciences, Irvine2 Vascular Laboratory, G D’Annunzio University, and San Valentino and Vasto Vascular Screening Project, and St Lucia Clinic, Sulmona

G. Acerbi, MD

Neurosurgery, Pisa, Surgery, Osp Frascati, Italy

P. Bavera, MD

Angiology and Vascular Surgery, University of Milan

A. Di Renzo

Department of Biomedical Sciences, Irvine2 Vascular Laboratory, G D’Annunzio University, and San Valentino and Vasto Vascular Screening Project, and St Lucia Clinic, Sulmona

M. Corsi, MD

Department of Biomedical Sciences, Irvine2 Vascular Laboratory, G D’Annunzio University, and San Valentino and Vasto Vascular Screening Project, and St Lucia Clinic, Sulmona

M. Scoccianti, MD

Department of Biomedical Sciences, Irvine2 Vascular Laboratory, G D’Annunzio University, and San Valentino and Vasto Vascular Screening Project, and St Lucia Clinic, Sulmona

M. Hosoi, MD, PhD

Department of Biomedical Sciences, Irvine2 Vascular Laboratory, G D’Annunzio University, and San Valentino and Vasto Vascular Screening Project, and St Lucia Clinic, Sulmona

M. Lania, MD

The aim of this study was to evaluate the prevention of recurrent deep vein thrombosis (RDVT) with an oral antithrombotic agent (sulodexide) in moderate to high-risk subjects. A group of 405 patients was included into the multicenter registry. Both compression and an exercise program were used as well as a risk-factors control plan. After diagnosis of DVT, patients were treated with oral anticoagulants for 6 months. At the end of this period a coagulation study was made and patients started treatment with oral sulodexide capsules for a period of 24 months. The femoral, popliteal, tibial, and superficial veins were scanned with high-resolution ultrasound at inclusion; scans were repeated at 6, 12, 18, and 24 months. Of the 405 subjects included into the registry 178 in the control group (mean age 52.2; SD 11; M:F = 90:88) and 189 in the treatment group (mean age 53.2; SD 10.3; M:F = 93:96) completed the analysis period of 24 months. At 6 and 12 months the incidence of R-DVT was lower (p<0.05) in the treatment group. At 24 months the global incidence of R-DVT was 17.9% in the control group and 7.4% in the sulodexide group (p<0.05), 2.42 times lower than in controls. The 2 groups were comparable for age and sex distribution and for the localization of the thrombi at inclusion. Also the 2 groups of dropouts were comparable. In the control group there were 32 recurrent DVTs and 24 subjects lost to follow-up (total of 56) of 202 included subjects (27.7%) in comparison with 28 failures (14 recurrent DVTs and 14 lost subjects) of 203 subjects (13.8%) in the treatment group. This difference was statistically significant. In this analysis the incidence of DVT in controls was 2.07 times higher than in the treatment group subjects. In conclusion sulodexide was effective in reducing recurrent thrombotic events in high-risk subjects.

Angiology, Vol. 55, No. 3, 243-249 (2004)
DOI: 10.1177/000331970405500302


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				J. L. Cirujeda and P. C. Granado A Study on the Safety, Efficacy, and Efficiency of Sulodexide Compared with Acenocoumarol in Secondary Prophylaxis in Patients with Deep Venous Thrombosis Angiology, January 1, 2006; 57(1): 53 - 64. [Abstract] [PDF]