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Sex Difference in the Effect of ACE-DD Genotype on the Risk of Premature Myocardial Infarction

Daniel Petrovi, MD, PhD

Institute of Histology and Embryology, Medical Faculty, University of Ljubljana, daniel.petrovic{at}mf.uni-lj.si

Dejan Bregar

Institute of Histology and Embryology, Medical Faculty, University of Ljubljana

Barbara Guzic-Salobir, MD, PhD

Department of Vascular Diseases, Medical Center Ljubljana

Erik Skof, MD

Department of Vascular Diseases, Medical Center Ljubljana

Matjaz Span, MD

Department of Vascular Diseases, Medical Center Ljubljana

Rifet Terzi, MD, PhD

Department of Biology, Medical Faculty, University Tuzla, Bosnia and Herzegovina

Mojca Globocnik Petrovi, MD, BSc

Eye Clinic, Medical Center Ljubljana

Irena Keber, MD, PhD

Department of Vascular Diseases, Medical Center Ljubljana

Mitja Letonja, MD, BSc

Department of Internal Medicine, General Hospital Ptuj

Marjeta Zorc, MD, PhD

Department of Intensive Medicine, General Hospital Celje

Matej Podbregar, MD, PhD

Department of Intensive Medicine, General Hospital Celje

Borut Peterlin, MD, PhD

Division of Medical Genetics, Department of Obstetrics and Gynecology, Medical Center Ljubljana, Slovenia

In this association study the authors compared the insertion/deletion (I/D) angiotensin-I converting enzyme (ACE) gene polymorphism in females and males with premature myocardial infarction (MI). I/D ACE gene polymorphism was tested in 738 subjects: 302 patients with MI (151 men and 151 women) and 436 healthy subjects (207 men and 229 women). In women the ACE-DD genotype was not associated with MI (OR 1.1, 95% CI 0.6-2.1, p=0.6), whereas the ACE-DD genotype conferred a 2-fold independent risk for MI in men (95% CI=1.2-3.4; p=0.013) after adjustment for cardiovascular risk factors. The authors found evidence for the sex difference in the effect of the ACE-DD genotype on MI risk. The ACE-DD genotype conferred a 2-fold independent risk for premature MI in males.

Angiology, Vol. 55, No. 2, 155-158 (2004)
DOI: 10.1177/000331970405500207


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