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Angiology
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A Pedigree Analysis of Familial Hypercholesterolemia in Monozygote Twin Brothers

Jian-Jun Li, MD, PhD

Department of Cardiology, Renmin Hospital, Wuhan University School of Medicine, Wuhan; Tsinghua University School of Medicine, Beijing, People's Republic of China.

Ming-Zhe Chen, MD

Tsinghua University School of Medicine, Beijing, People's Republic of China.

Xin Chen, MD

Tsinghua University School of Medicine, Beijing, People's Republic of China.

The current study was designed to investigate the features of a family with familial hyperc holesterolemia (FH). Twenty members of 3 generations in a family with hypercholesterolemia were enrolled in the study. The data collected were from clinical observation and subjected to pedigree analysis. The proband was a 41-year-old male who suffered from angina pectoris with multi-vessel stenosis of coronary arteries at the age of 40. Among 20 members, 8 indi viduals had FH in this family with a total incidence of 40% (54.5% [6/11] in male and 22.2% [2/9] in female). The serum total cholesterol level was increased in childhood from 7.1 to 10.8 mmol/L and tended to increase with increasing age. In addition, the level of total cholesterol was increased in monozygote twin brothers and their offspring in the family. This pedigree analysis showed that FH appears to be a hereditary disease of autosomal dominance, and attention should be paid, especially in the only son or daughter society of China.

Angiology, Vol. 54, No. 6, 711-713 (2003)
DOI: 10.1177/000331970305400611
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