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A New Noninvasive Method for the Accurate and Precise Assessment of Varicose Vein Diameters

Linda Pustina, PhD

Samuela Castelnuovo

Alighiero Bondioli, MD

Matteo Carlà, MD

Cesare R. Sirtori, PhD, MD

The feasibility and reproducibility of a new ultrasonic method for the direct assessment of maximal varicose vein diameter (VVD) were evaluated. A study was also performed to demon strate the capacity of the method to detect changes in venous diameter induced by a phar macologic treatment. Patients with varicose vein disease were recruited. A method that allows the precise positioning of patient and transducer and performance of scans in a gel-bath was developed. Maximal WD was recorded both in the standing and supine positions. The intraassay reproducibility was determined by replicate scans made within 15 minutes in both positions. The interobserver variability was assessed by comparing WDs measured during the first phase baseline examination with those obtained during baseline examinations in the second phase of the study. The error in reproducibility of WD determinations was 5.3% when diameters were evaluated in the standing position and 6.4% when assessed in the supine position. The intramethod agreement was high, with a bias between readings of 0.06 ±0.18 mm and of -0.02 ±0.19 mm, respectively, in standing and supine positions. Correlation coefficients were better than 0.99 in both positions. The method appears to be sensitive enough to detect small changes in VVDs induced by treatments. The proposed technique provides a tool of potential valid use in the detection and in vivo monitoring of WD changes in patients with varicose vein disease. The method offers an innovative approach to obtain a quantitative assessment of varicose vein progression and of treatment effects, thus providing a basis for epidemiologic surveys.

Angiology, Vol. 54, No. 5, 541-549 (2003)
DOI: 10.1177/000331970305400503


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