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Deficiency of Protein S-Mediated Familial Venous Thrombophilia

A Case Report

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo.

Hiroyuki Morita, MD

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo.

Yasushi Imai, MD

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo.

Doubun Hayashi, MD

Department of Pharmacoepidemiology, Graduate School of Medicine, The University of Tokyo.

Norihiko Takeda, MD

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo.

Koji Maemura, MD

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo.

Yoshio Yazaki, MD

The Hospital International Medical Center of Japan, Tokyo, Japan.

Ryozo Nagai, MD

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo.

Deficiency of protein S causes potential problems of thrombosis. Cases of familial venous thrombosis due to deficiency of protein S were presented. First, an 85-year-old woman had pulmonary thromboembolism due to left deep femoral venous thrombosis, which might be triggered by leg fracture and the long-term treatment with a plaster cast. Next, her 29-year- old granddaughter had episodes of recurrent venous thrombosis in her legs and arms, which might be triggered by the treatment with a plaster cast and abortion. In the latter part, the aspects of risks for thromboembolism, potential problems in gestational period, and an advis ability of thromboprophylaxis in patients with deficiency of protein S are described.

Angiology, Vol. 54, No. 3, 377-381 (2003)
DOI: 10.1177/000331970305400317


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