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Angiology
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*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*PROSTAGLANDIN F2ALPHA
Medline Plus Health Information
*Varicose Veins
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8-epi-PGF 2{alpha} and 6-oxo-PGF{alpha} in Human (Varicose) Veins: Influence of Age, Sex, and Risk Factors

Susan Meghdadi, MD

Department of Nuclear Medicine, University of Vienna, Vienna, Austria.

Margarida Rodrigues

Department of Nuclear Medicine, University of Vienna, Vienna, Austria.

A. Oguogho, DDr

Department of Physiology, Faculty of Basic Medical Sciences, Edo State University, Ekpoma, Nigeria.

R. Santler

Department of Nuclear Medicine, University of Vienna, Vienna, Austria.

H. Sinzinger

Department of Nuclear Medicine, University of Vienna, Vienna, Austria.

The isoprostane 8-epi PGF 2{alpha} is a vasoconstrictive, mitogenic, proliferative, and mild proaggre gatory agent. We examined 8-epi-PGF 2{alpha} and 6-oxo-PGF1{alpha} from venous tissue derived from varicose (venous) surgery by means of a specific radioimmunoassay. A total of 336 samples from 82 patients (50 females, 32 males; aged 22-68 years) were examined. Tissue samples were classified according to normal, dilated, and varicose. Of these, 94 samples from 31 patients (20 females, 11 males; aged 29-64 years) with additional risk factors (cigarette smoking, hyperlipidemia, diabetes mellitus) were determined in the same way. Mean absolute values for 6-oxo-PGF1{alpha} are not significantly higher for dilated segments followed by varicose and intact samples. No significant age and sex differences can be monitored. Presence of risk factors, however, results in a significantly diminished 6-oxo-PGF1{alpha}, irrespective of morphology. 8-epi-PGF 2{alpha} again showed no age and sex dependence, its presence in varicose segments, however, was significantly (p<0.01) decreased. Risk factors resulted in a significantly increased 8-epi-PGF2{alpha}. These data indicate that the influence of risk factors on vasomodulatory (iso-)eicosanoids of human veins is more pronounced than the actual morphologic stage. Lower 8-epi-PGF2{alpha} in varicose veins may shift the venous tone toward vasodilatation and contribute to development and progression of varicosis.

Angiology, Vol. 54, No. 3, 317-324 (2003)
DOI: 10.1177/000331970305400307
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