SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Angiology
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Meghdadi, S.
Right arrow Articles by Sinzinger, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Meghdadi, S.
Right arrow Articles by Sinzinger, H.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

8-epi-PGF 2{alpha} and 6-oxo-PGF{alpha} in Human (Varicose) Veins: Influence of Age, Sex, and Risk Factors

Susan Meghdadi, MD

Department of Nuclear Medicine, University of Vienna, Vienna, Austria.

Margarida Rodrigues

Department of Nuclear Medicine, University of Vienna, Vienna, Austria.

A. Oguogho, DDr

Department of Physiology, Faculty of Basic Medical Sciences, Edo State University, Ekpoma, Nigeria.

R. Santler

Department of Nuclear Medicine, University of Vienna, Vienna, Austria.

H. Sinzinger

Department of Nuclear Medicine, University of Vienna, Vienna, Austria.

The isoprostane 8-epi PGF 2{alpha} is a vasoconstrictive, mitogenic, proliferative, and mild proaggre gatory agent. We examined 8-epi-PGF 2{alpha} and 6-oxo-PGF1{alpha} from venous tissue derived from varicose (venous) surgery by means of a specific radioimmunoassay. A total of 336 samples from 82 patients (50 females, 32 males; aged 22-68 years) were examined. Tissue samples were classified according to normal, dilated, and varicose. Of these, 94 samples from 31 patients (20 females, 11 males; aged 29-64 years) with additional risk factors (cigarette smoking, hyperlipidemia, diabetes mellitus) were determined in the same way. Mean absolute values for 6-oxo-PGF1{alpha} are not significantly higher for dilated segments followed by varicose and intact samples. No significant age and sex differences can be monitored. Presence of risk factors, however, results in a significantly diminished 6-oxo-PGF1{alpha}, irrespective of morphology. 8-epi-PGF 2{alpha} again showed no age and sex dependence, its presence in varicose segments, however, was significantly (p<0.01) decreased. Risk factors resulted in a significantly increased 8-epi-PGF2{alpha}. These data indicate that the influence of risk factors on vasomodulatory (iso-)eicosanoids of human veins is more pronounced than the actual morphologic stage. Lower 8-epi-PGF2{alpha} in varicose veins may shift the venous tone toward vasodilatation and contribute to development and progression of varicosis.

Angiology, Vol. 54, No. 3, 317-324 (2003)
DOI: 10.1177/000331970305400307
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




Advertisement