This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Karavidas, A. J. Articles by Zacharoulis, A. A. Search for Related Content PubMed PubMed Citation Articles by Karavidas, A. J. Articles by Zacharoulis, A. A. Social Bookmarking                         What's this?

Primary Stenting Produces Earlier and More Efficient Myocardial Reperfusion than Primary PTCA Alone in Patients with Acute ST Segment Elevation MI

Department of Cardiology, University of Athens Hospital, Athens, Greece; and the Department of Medicine, St. John's Mercy Medical Center, St. Louis, MO.

Antony D. Vrachatis, MD

Department of Cardiology, University of Athens Hospital, Athens, Greece; and the Department of Medicine, St. John's Mercy Medical Center, St. Louis, MO.

Martin A. Alpert, MD, FACA

Department of Medicine, St. John's Mercy Medical Center, St. Louis, MO.

Dimitris J. Nikas, MD

Department of Cardiology, University of Athens Hospital, Athens, Greece; and the Department of Medicine, St. John's Mercy Medical Center, St. Louis, MO.

Dimitrious J. Achtypis, MD

Department of Cardiology, University of Athens Hospital, Athens, Greece; and the Department of Medicine, St. John's Mercy Medical Center, St. Louis, MO.

Masolis G. Foukarakis, MD

Department of Cardiology, University of Athens Hospital, Athens, Greece; and the Department of Medicine, St. John's Mercy Medical Center, St. Louis, MO.

Evangelos P. Matsakus, MD

Department of Cardiology, University of Athens Hospital, Athens, Greece; and the Department of Medicine, St. John's Mercy Medical Center, St. Louis, MO.

Costas S. Thedocharis, MD

Department of Cardiology, University of Athens Hospital, Athens, Greece; and the Department of Medicine, St. John's Mercy Medical Center, St. Louis, MO.

Apostolos A. Zacharoulis, MD

Department of Cardiology, University of Athens Hospital, Athens, Greece; and the Department of Medicine, St. John's Mercy Medical Center, St. Louis, MO.

Restoration of blood flow in the infarct-related artery and subsequent myocardial reperfusion are major goals of both thrombolysis and primary percutaneous interventions. Whether percu taneous transluminal coronary angioplasty (PTCA) with immediate stenting (primary stenting) produces reperfusion more rapidly than primary PTCA alone is uncertain. This study deter mines whether primary stenting produces earlier myocardial reperfusion than primary PTCA alone in patients with acute ST segment elevation myocardial infarction using troponin T release kinetics. Primary stenting was performed on 60 patients and primary PTCA alone on 44 patients with typical ischemic chest pain and greater than 1.5 MV ST segment elevation in more than 2 contiguous electrocardiographic leads. Serum troponin T concentrations were measured before and after intervention; every 6 hours for 24 hours; then at 36, 48 and 72 hours. The mean time from onset of chest pain to peak serum troponin T concentration was 7.8 ±2.7 hours after primary stenting and 14.5 ±4.4 hours after primary PTCA (p < 0.0005). The mean peak serum troponin T concentration was 9.8 ±6.3 ng/dL after primary stenting and 13.6 ±6.4 ng/dL after primary PTCA (p < 0.012). A significant univariate association with time to peak concentration of serum troponin T was identified for primary stenting (p < 0.0005), time from onset of chest pain to intervention (p < 0.04), and diabetes mellitus (p < 0.01). The only significant univariate marker associated with peak concentration of serum troponin T was primary stenting (p < 0.012). Multivariate analysis indicated that primary stenting (p < 0.0005), time from onset of chest pain to intervention (p < 0.048), and diabetes mellitus (p < 0.022) significantly influenced time to peak serum concentration or troponin T. Primary stenting produces earlier myocardial reperfusion than primary PTCA in patients with acute ST segment elevation myocardial infarction.

Angiology, Vol. 54, No. 2, 195-203 (2003)
DOI: 10.1177/000331970305400209


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?