This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Kolovou, G. D. Articles by Cokkinos, D. V. Search for Related Content PubMed PubMed Citation Articles by Kolovou, G. D. Articles by Cokkinos, D. V. Social Bookmarking                   What's this?

The Epsilon 2 and 4 Alleles of Apolipoprotein E and Ischemic Vascular Events in the Greek Population — Implications for the Interpretation of Similar Studies

Deliana Ch. Daskalova, MD

Marilena Hatzivassiliou, MSc

Nikos Yiannakouris, PhD

Nektarios D. Pilatis, MD

Moses Elisaf, MD

Dimitri P. Mikhailidis, MD

Marios A. Cariolou, MSc, PhD

Dennis V. Cokkinos, MD

The authors investigated whether apolipoprotein (apo) E polymorphism has an allelic and/or genotypic impact on the risk of an ischemic vascular event (IVE) in Greek patients with cardio vascular diseases (CVD). They compared apo E polymorphisms in 1) a group of 165 patients with IVE [IVE(+)], of whom 107 had survived a myocardial infarction and 58 an ischemic stroke; 2) a group of 165 patients, matched with the first group for age and gender, with angio graphically confirmed coronary artery disease but without IVE [IVE(-)]; 3) a group of 240 healthy younger individuals with no family history of CVD. The apo 2 allele was 5.2-fold less frequent in the IVE(+) group compared to the IVE(-) group (1.2% vs 6.2%, p= 0.001). The frequency of the 2 allele in healthy subjects was 8.1 %, which is 6.7-fold higher than in the IVE(+) group (p < 0.001), and more than twice as high compared to all CVD patients (p = 0.001). No significant differences in 4 allele frequencies were observed between IVE(+) and IVE(-) patients (9.8% vs 8.4%) or between patients with CVD and healthy subjects (9.1% vs 10.2%). The 4 allele was not associated with an increased risk for CVD or IVE. In contrast, an inverse and beneficial association of the 2 allele with IVE was observed among Greek patients with CVD. These results suggest that the 4 and 2 alleles have a variable significance in terms of predicting the risk of vascular events in different populations. Therefore, it is important to carry out "local" studies.

Angiology, Vol. 54, No. 1, 51-58 (2003)
DOI: 10.1177/000331970305400107


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?