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Favorable Response to High-Dose Interferon-Alpha in Idiopathic Hypereosinophilic Syndrome with Restrictive Cardiomyopathy

Case Report and Literature Review

Antonella Afeltra, MD

Massimo Delfino, MD

Stefano De Castro, MD

Flavia Giorgino, MD

Filippo Rossi-Fanelli, MD

The idiopathic hypereosinophilic syndrome is characterized by a prolonged overproduction of eosinophils of unknown cause in addition to specific organ damage due to eosinophil-derivated protein toxicity. Its prognosis is correlated with heart involvement that results in a restrictive cardiomyopathy. This is frequently biventricular. Isolated left ventricular infiltration has rarely been reported. The authors report a case of idiopathic hypereosinophilic syndrome with cardiac involvement obliterating the left ventricular cavity with a favorable clinical outcome following a combination therapy with interferon-alpha, hydroxyurea and prednisone. Data from other studies dealing with the treatment of idiopathic hypereosinophilic syndrome with interferon- alpha are reviewed and discussed.

Angiology, Vol. 53, No. 4, 465-470 (2002)
DOI: 10.1177/000331970205300414


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