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Evaluation of Plasma Endothelin-1 Levels in Patients with Cerebral Infarction

Trabzon, Turkey

Asim Örem, MD

Trabzon, Turkey

Ismail Bülbül, MD

Trabzon, Turkey

Cavit Boz, MD

Trabzon, Turkey

Mehmet Özmenolu, MD

Trabzon, Turkey

Birgül Vanizor, PhD

Trabzon, Turkey

Endothelin-1 (ET-1) is a vasoconstrictor peptide derived from endothelium. Many authors have shown that ischemic stroke is associated with elevated plasma ET-1 levels. Also, the present findings related to plasma ET-1 levels with clinical status, size of the infarction, location of the infarction, and prognosis of the cerebral infarction were contradictory. In this study, plasma ET-1 levels in 30 patients with cerebral infarction within 72 hours after the onset of focal neurologic deficit and at their seventh day postinfarction were measured by a microplate enzyme immunoassay. Thirty sex- and age-matched healthy subjects were accepted as a control group. The mean plasma ET-1 concentrations in patients on admission, in patients at day 7, and in control subjects were 1.93 ± 1.79, 1.03 ± 1.02, and 0.65 ±0.32 fmol/mL, respec tively. The mean plasma ET-1 level of patients on admission was found to be significantly higher than in patients at day 7 and in control subjects (p < 0.05). No significant difference in ET-1 levels was observed between the patients at day 7 and control subjects. Furthermore, there was no correlation between plasma ET-1 concentration and size of infarction, location of infarction, degree of clinical neurologic deficit, or prognosis of cerebral infarction. It was concluded that plasma ET-1 levels shortly after ischemic stroke were increased, which may be associated with the acute-phase reaction of cerebral infarction and may have deleterious effects on development of neuronal injury.

Angiology, Vol. 53, No. 1, 77-82 (2002)
DOI: 10.1177/000331970205300110


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