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Extent of Coronary Atherosclerosis and Homocysteine Affect Endothelial Markers

S. Lale Tokgozoglu, MD, FACC, FESC

Ibrahim Haznedaroglu, MD

Incilay Sinici, MD

Giray Kabakci, MD

Kenan Ovunc, MD

Serdar Aksoyek, MD

Ali Oto, MD, FESC, FACC

Ferhan Ozmen, MD

Serafettin Kirazli

Sirri Kes, MD

The aim of the study was to evaluate the effects of the presence, extent, and clinical stability of coronary artery disease on endothelial function parameters, C-reactive protein and homo cysteine levels. Fifty-eight patients with angiographically documented coronary artery disease and 25 patients with normal coronary arteries were evaluated for risk factors, plasma homo cysteine, C-reactive protein, and soluble adhesion molecule levels. Vascular cell adhesion molecule-1 and sE-selectin were significantly higher in the group with coronary artery disease than in healthy subjects (p = 0.005 and p = 0.031, respectively). Patients with unstable angina had significantly higher C-reactive protein (p< 0.001), troponin I (p<0.01), and leukocyte counts (p < 0.05) than those with stable angina. sE-selectin levels were correlated with the extent of coronary atherosclerosis (r = 0.444, p < 0.05), and plasma homocysteine levels were associated with vascular cell adhesion molecule-1 (r= 0.479, p<0.05) in unstable cases. These results suggest that vascular cell adhesion molecule-1 and sE-selectin are useful for determining the presence of coronary atherosclerosis, whereas C-reactive protein, troponin I, and leukocyte count are predictors of clinical stability.

Angiology, Vol. 52, No. 9, 589-596 (2001)
DOI: 10.1177/000331970105200902


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