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Intact Insulin, Insulin Propeptides, and Intima-media Thickness in the Femoral Artery in 58-year-old Clinically Healthy Men

The Atherosclerosis and Insulin Resistance Study

Department of Medicine, Sahlgrenska University Hospital, Gbteborg University, G6teborg, Sweden.

J. Wikstrand, MD, PhD

Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Gbteborg University, G6teborg, Sweden.

B. Fagerberg, MD, PhD

Department of Medicine, Sahlgrenska University Hospital, Gbteborg University, G6teborg, Sweden.

The aim of this study was to examine the association between intact insulin, insulin propep tides, and femoral artery intima-media thickness. The design was a cross-sectional study and the study group (n = 391) consisted of randomly recruited clinically healthy 58-year-old Swedish men. The intima-media thickness of the common femoral artery was measured with ultrasound. Fasting plasma insulin; intact insulin; proinsulin; 32,33 split-proinsulin; and C-peptide concen trations were assessed.

The results showed that the common femoral artery intima-media thickness correlated significantly and univariately with waist-hip ratio, systolic blood pressure, serum total choles terol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, ApoB, low-density lipoprotein peak particle size, and cigarette years. Furthermore, of intact insulin and insulin propeptides, only intact insulin and C-peptide were univariately associated with common femoral artery intima-media thickness (r= 0.14, p < 0.01; r= 0.18, p < 0.01; respec tively). In a multiple regression analysis, common femoral artery intima-media thickness was independently associated with systolic blood pressure (beta-coefficient = 0.004, p = 0.002), ApoB (beta-coefficient = 0.338, p < 0.001) and cigarette years (beta-coefficient = 0.0004, p < 0.001), (R² = 25%, p < 0.00 1 ).

In conclusion, smoking, systolic blood pressure, and ApoB but not insulin or insulin propep tides were independently associated with femoral atherosclerosis.

Angiology, Vol. 52, No. 4, 237-245 (2001)
DOI: 10.1177/000331970105200402


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