This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Incandela, L. Articles by Griffin, M. Search for Related Content PubMed PubMed Citation Articles by Incandela, L. Articles by Griffin, M. Social Bookmarking                   What's this?

Microvascular Alterations in Diabetic Microangiopathy: Topical Treatment with Essaven Gel

A Placebo-Controlled, Randomized Study

G. Belcaro

M.R. Cesarone

M.T. De Sanctis

M. Griffin

The involvement of the microcirculation in diabetic microangiopathy (DM) may be cause of severe invalidity and ulceration. Diabetic microangiopathy (DM) is characterized by a diffuse increase in skin flux, reduction in venoarteriolar response, and increased capillary permeability resulting in edema; skin PO₂ is decreased and CO₂ increased. In this condition, capillary exchanges are altered and nutritional alterations eventually lead to skin lesions and ulcers. The aim of this randomized, placebo-controlled study was to evaluate the effect of local foot care and treatment with Essaven gel (EG) in 30 subjects with DM and neuropathy and localized, small (<0.5 cm in maximum diameter) ulcers treated with a single acute application of EG. Measurements of laser Doppler (LDF) flux, PO₂ and PCO₂ in standardized conditions showed positive microcirculatory changes (a significant decrease of the abnormally increased flux and CO₂ while PO₂ increased) in the active EG group lasting for at least 6 hours after application. Changes in the control group were not significant. In the placebo group variations were limited, mainly associated with skin manipulation and gel application. In conclusion, local treatment with one single standardized application of Essaven gel, in comparison with placebo, acutely improves the microcirculation in subjects with DM and small ulceration even with a single acute application. The microcirculatory changes are detectable even 10 hours after application.

Angiology, Vol. 52, No. 3 suppl, S35-S41 (2001)
DOI: 10.1177/000331970105200308


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?