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Changes in Microcirculation in Venous Ulcers with Essaven Gel

A Pilot, Cross-over, Placebo-Controlled, Randomized Study

G. Belcaro

M.R. Cesarone

M.T. De Sanctis

M. Griffin

Microcirculatory changes in chronic venous insufficiency (CVI) due to venous hypertension produce venous hypertensive microangiopathy (VHM) and lead to ulceration. VHM is charac terized by enlarged, convoluted capillaries; increase in flux, permeability, and edema; and altered microlymphatics. PO₂ is decreased and CO₂ increased. Capillary exchanges are altered and nutritional alterations in association with microtrauma may cause venous ulcers. The aim of this pilot, cross-over, randomized, placebo-controlled study was to evaluate the effect of local treatment with Essaven gel (EG) (single acute application) in 10 subjects with VHM and venous ulcers. The study was structured over 3 days: day 1 was used for the control evalua tion for all patients. One group was randomized for the sequence placebo (day 2) and EG the following day; the second group with the sequence EG (day 2) and placebo (day 3). Indepen dently from the sequence, measurements of flux and PO₂ in standard conditions showed positive changes (significant decrease of the abnormally increased flux, PO₂ increase) in the EG treatment group. Changes in the placebo group were limited and associated with skin manip ulation. In conclusion, EG acutely improves microcirculation in limbs with VHM and ulceration even with a single application.

Angiology, Vol. 52, No. 3 suppl, S23-S27 (2001)
DOI: 10.1177/000331970105200306


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