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tPA via Infusion Catheters Followed by Continuous IV Infusion for 3 Days Prevents Intimal Hyperplasia After Balloon Injury

Osaka, Japan

Yoshikazu Inoue, MD

Osaka, Japan

Narutaka Otani, MD

Osaka, Japan

Norikatsu Naito, MD

Osaka, Japan

Hideki Morii, MD

Osaka, Japan

Akiko Ikeda, MD

Osaka, Japan

Mitsugu Taniguchi, MD

Osaka, Japan

Norihiro Ishida, MD

Osaka, Japan

Takahiro Hayashi, MD

Osaka, Japan

Kinji Ishikawa, MD

Osaka, Japan

A rabbit model was used to examine the effects of tissue plasminogen activator (tPA) on development of intimal hyperplasia following balloon injury. Thirty-two hereditary hypercho lesterolemic (KHC) rabbits underwent percutaneous transluminal coronary artery balloon catheterization and injury to the common iliac artery, after which they were divided into four groups: untreated (control); Dispatch catheterized-30 minutes local saline delivery [D(+)- tPA(-)]; D(+)-30 minutes local tPA delivery (0.6 mg/kg) [D(+)-tPA(30 min)]; and D(+)-30 minutes local tPA + 3 days intravenous infusion (0.6 mg/kg/24 h) [(D(+)-tPA(30 min + 3 d)]. Twenty-eight days later, the intimal cross-sectional areas of all three Dispatch catheterized groups were significantly smaller than those of control groups, as were the intimal/medial area ratios. Moreover, the intima/media ratios of the D(+)-tPA(30 min + 3 d) group were significantly smaller than those of the D(+)-tPA(-) group. Thus, local delivery of tPA via Dispatch catheters followed by continuous intravenous infusion of tPA for 3 days prevented intimal hyperplasia after angioplasty.

Angiology, Vol. 52, No. 12, 819-825 (2001)
DOI: 10.1177/000331970105201203


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