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Monoclonal Cryoglobulinemia with Extensive Gangrene of All Four Extremities

A Case Report

Joel M. Schwartz, MD

Sandor Friedman, MD

Shafkat Hussain, MD

Coney Island Hospital 2601 Ocean Parkway, Room 9N8 Brooklyn, NY 11235

The monoclonal immunoglobulin products of plasma cell neoplasm can give rise to a variety of manifestations including hyperviscosity, amyloidosis, cryoglobulinemia, neuropathy, and renal failure. A 50-year-old woman with monoclonal cryoglobulinemia developed extensive gangrene and ulceration of both hands and feet over several weeks requiring bilateral below-elbow and below-knee amputations. This case illustrates the importance of qualitative properties of paraprotein.

Angiology, Vol. 51, No. 5, 431-434 (2000)
DOI: 10.1177/000331970005100511


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