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Prothrombin Gene 20210 GA and Factor V Arg 506 to Gln Mutation in a Patient with Buerger's Disease

A Case Report

Nejat Akar, MD

Ece Akar, BSc, MSc

Cengiz Beyan, MD

Atilla Yalçin, MD

Department of Hematology Gülhane Military Medical Academy 06018-Etlik/Ankara, Turkey

Thromboangiitis obliterans, or Buerger's disease, is a segmental occlusive inflammatory disorder of the arteries and veins most commonly affecting the lower extremities of young male cigarette smokers. The etiopathogenesis of the thromboangiitis obliterans is still obscure. The authors have identified heterozygosity for the recently described prothrombin gene 20210 GA variation and Factor V Arg 506 to Gln (Factor V Leiden) mutation in a patient with Buerger's disease. Both mutations confer a high risk of throm bosis. This coincidental observation may serve as further evidence that a thrombotic mechanism is involved in Buerger's disease.

Angiology, Vol. 51, No. 5, 421-423 (2000)
DOI: 10.1177/000331970005100509


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