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Angiology
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Ischemic Preconditioning: The Endogenous Power

A Review of the Literature

Ahmed A. Alsaddique, MD, FACS

Division of Cardiac Surgery College of Medicine and King Khaled University Hospital PO Box 55952 Riyadh 11544 Saudi Arabia

With the re-emergence of surgery on a beating heart, it is important to examine the unique phenomenon of ischemic preconditioning (IPC) and its role as a form of myocardial protec tion under these circumstances. Ischemic preconditioning is defined as a short period of ischemia, regional or global, imposed before a more prolonged period of ischemia, which increases the myocardium's tolerance to ischemia by endogenous adaptive mechanism. 1 Until recently, it was generally held that repeated ischemic episodes would have a cumu lative adverse effect and could lead to a "stuttering infarction."

Angiology, Vol. 51, No. 5, 355-360 (2000)
DOI: 10.1177/000331970005100501


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