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Coronary Spastic Angina Induced by Anticholinesterase Medication for Myasthenia Gravis

A Case Report

Second Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan.

Toyofumi Yoshii, MD

Second Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan.

Tomoaki Ohtsuka, MD

Second Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan.

Osamu Sasaki, MD

Second Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan.

Yuji Hara, MD

Second Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan.

Takafumi Okura, MD

Second Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan.

Yuji Shigematsu, MD

Second Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan.

Mareomi Hamada, MD

Second Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan.

Kunio Hiwada, MD, FACA

Second Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan.

Myasthenia gravis (MG) is characterized by weakness of skeletal muscles because of a decrease in the number of available acetylcholine receptors at neuromuscular junctions. Anticholinesterase medication is widely used to treat MG, but muscarinic side effects sometimes appear and limit the drug usage. To their knowledge, the authors present the first case of coronary spastic angina quite possibly induced by anticholinesterase medica tion to treat MG. The appearance of coronary spastic angina in the present case is likely mediated through the increase of acethylcholine by anticholinesterase medication.

Angiology, Vol. 51, No. 12, 1031-1034 (2000)
DOI: 10.1177/000331970005101209


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