This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Sayinalp, N. Articles by Gürgey, A. Search for Related Content PubMed PubMed Citation Articles by Sayinalp, N. Articles by Gürgey, A. Social Bookmarking                         What's this?

Paget-Schroetter Syndrome Associated with FV:Q506 and Prothrombin 20210A

A Case Report

Departments of Hematology, Eser Sitesi B-3 /10 Bahçelievler Ankara 06490 Turkey

Osman Ilhami Özcebe, MD

Departments of Hematology, Hacettepe University Medical School, Ankara 06490 Turkey

erafettin Kirazli

Departments of Hematology, Hacettepe University Medical School, Ankara 06490 Turkey

Riza Doan, MD

Departments of Cardiovascular Surgery, Hacettepe University Medical School, Ankara, Turkey

Semra V. Dündar, MD

Departments of Hematology, Hacettepe University Medical School, Ankara 06490 Turkey

Aytemiz Gürgey, MD

Departments of Cardiovascular Surgery, Hacettepe University Medical School, Ankara, Turkey

Effort thrombosis of the axillary-subclavian vein (Paget-Schroetter syndrome) develops usually secondary to heavy arm exertion. An underlying chronic venous compressive anomaly at the thoracic outlet or intimal damage of the axillary vein following forceful hyperabduction, external rotation of the shoulder joint has been proposed to explain the pathophysiology of this thrombosis. This condition is usually not attributed to an under lying hypercoagulability such as deficiency of natural coagulation inhibitors. Here, the authors present a case with thrombosis of the axillary-subclavian vein following an effort, with factor V Leiden and prothrombin 20210A mutations. Both factor V Leiden and the genetic variant in the prothrombin gene have been shown to confer an increased risk for venous thrombosis. Although rare, effort thrombosis may develop in a patient with hereditary thrombophilia, so laboratory evaluation should include the common causes of thrombosis.

Angiology, Vol. 50, No. 8, 689-692 (1999)
DOI: 10.1177/000331979905000811


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?