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A Missense Mutation of the Nitric Oxide Synthase (eNOS) Gene (Glu298Asp) in Five Patients with Coronary Artery Disease

Case Reports

Departments of Internal Medicine, Fukuoka University School of Medicine, Fukuoka 814-80, Japan

Keijiro Saku, MD, FACP, FACA

Department of Internal Medicine Fukuoka University School of Medicine 7-45-1 Nanakuma Jonan-ku Fukuoka 814-80, Japan

Jiafu Ou, MD

Departments of Internal Medicine, Fukuoka University School of Medicine, Fukuoka 814-80, Japan

Shiro Jimi, PhD

Departments of Internal Medicine, Fukuoka University School of Medicine, Fukuoka 814-80, Japan

Bo Zhang, PhD

Departments of Internal Medicine, Fukuoka University School of Medicine, Fukuoka 814-80, Japan

Kazuyuki Shirai, MD

Departments of Internal Medicine, Fukuoka University School of Medicine, Fukuoka 814-80, Japan

Kikuo Arakawa, MD, FACC

Departments of Internal Medicine, Fukuoka University School of Medicine, Fukuoka 814-80, Japan

The authors report five patients with a missense mutation of the endothelial nitric oxide synthase (eNOS) gene (Glu²⁹⁸Asp) who have angiographically proven coronary artery disease (CAD). They compare their clinical findings and coronary arteriographic charac teristics. They conclude that these case reports show that this mutation is not solely responsible for development of CAD. Diabetes mellitus, smoking, and hyperlipidemia are other risk factors.

Angiology, Vol. 50, No. 8, 671-676 (1999)
DOI: 10.1177/000331979905000808


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