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Intravenous Hydroxyethylrutosides Combined with Long-Term Oral Anticoagulation in Atherosclerotic Nonreconstructable Critical Leg Ischemia: A Retrospective Study

Departments of Clinical Physiology of Karolinska Hospital and Södersjukhuset, and Clinical Research Centre of Södersjukhuset, Stockholm, Sweden.

Per-Olov Glenne, MSc

Departments of Clinical Physiology of Karolinska Hospital and Södersjukhuset, Stockholm, Sweden.

Jorge Inácio, MSc

Departments of Clinical Physiology of Karolinska Hospital and Södersjukhuset, and Clinical Research Centre of Södersjukhuset, Stockholm, Sweden.

Ulla-Britt Larsson

Departments of Clinical Physiology of Södersjukhuset, Stockholm, Sweden.

Stig Lavstedt, PhD

Departments of Clinical Physiology of Karolinska Hospital and Södersjukhuset, Stockholm, Sweden.

Zhaomei Qian, MD

Departments of Clinical Physiology of Karolinska Hospital, and Clinical Research Centre of Södersjukhuset, Stockholm, Sweden.

Jörn Schiötz, BSc

Departments of Clinical Physiology of Karolinska Hospital and Södersjukhuset, Stockholm, Sweden.

Carl Tillgren, MD, PhD

Departments of Clinical Physiology of Karolinska Hospital and Södersjukhuset, Stockholm, Sweden.

Objective. To evaluate in a group of seriously diseased patients with nonreconstructable chronic critical leg ischemia (CLI), treated by a combination of IV hydroxyethylrutosides (HR)* and oral anticoagulation (AC) by warfarin, the short-term effects on the cutaneous microvascular blood perfusion of the soles of feet and especially the long-term clinical outcome in terms of amputation and death.

Design. A retrospective comparison between two groups of patients, HR + AC and a comparable reference group, fulfilling the same inclusion and exclusion criteria corre sponding to the definition of CLI according to the Second European Consensus Document (1991). Clinical follow-up in both groups was made after 1, 3, 6, 12, and 24 months.

Setting. Patients were examined at university departments of clinical physiology with special interest in peripheral vascular disease, in cooperation with colleagues at univer sity departments of surgery, internal medicine and dermatology of Karolinska Hospital, Södersjukhuset and Huddinge Hospital. (continued on next page) Patients. A total of seventy patients with CLI according to the definition of the Second European Consensus Document, 1991, ie, besides severe rest pain or ischemic lesions also a toe blood pressure < 30 mg Hg. Group with HR + anticoagulation (AC): 42 patients (19 diabetics, 23 nondiabetics). Reference group: 28 patients (18 diabetics, 10 nondiabetics). For distribution of age and toe blood pressure at baseline, see Table I.

Interventions. Therapy group: besides ordinary standard therapy, daily HR infusions for a mean period of 3.6 weeks + oral anticoagulation continued to the end of the study at 24 months. A comparable reference group on the same basic therapy but without the combination HR + AC.

Parameters In Evaluation. Short-term parameters: clinical data, skin temperature, and fluorescein imaging. Long-term outcome: amputation or death.

Results. Short-term and long-term results with HR + AC indicated that patients with severe CLI and very poor prognosis benefited in terms of survival and limb salvage from initial therapy with HR infusion combined with long-term oral anticoagulation. Results of this combined treatment seem at least comparable with those with IV prosta cyclin analogies.

Key Words: *Venoruton® • Paroven® • Novartis Pharmaceuticals • Switzerland.

Angiology, Vol. 50, No. 6, 433-445 (1999)
DOI: 10.1177/000331979905000601


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