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Histologic Comparison of Coronary and Iliac Atherectomy Tissue from Cases of In-Stent Restenosis

Chikao Yutani, MD

Masami Imakita, MD

Sachio Kuribayashi, MD

Makoto Takamiya, MD

Hideo Uchida, MD

Kimihiko Kichikawa, MD

Takahiko Suzuki, MD

Hatsue Ishibashi-Ueda, MD, PhD

Department of Pathology National Cardiovascular Center 7-1, Fujishirodai, 5-chome, Suita Osaka, Japan, 5658565

Pathologically, restenotic lesions after stenting were investigated by use of atherec tomized tissues of seven coronary and seven iliac arteries. The mean interval of the stent deployment to restenosis was 9.1 months for the coronary artery and 33.7 months for the iliac artery, indicating a 3.7-fold longer interval for the latter. This study does not include cases of acute thrombotic occlusion. The atherectomized tissue from restenotic coronary arteries showed abundant neointima with -actin-positive and ultrastructually synthetic- type smooth muscle cells in a rich myxomatous extracellular matrix. In the iliac arteries, the predominant component of restenosis consisted of organized thrombi. The neointima of the iliac arteries was mature, and only a small amount of spindle cells were observed in the hyalinized matrix. The tissue that developed restenosis after stenting was different in the coronary and iliac arteries included in this series. This study on the atherectomized tissue suggests that even in the chronic stage, a major cause of in-stent restenosis among the larger caliber vessels such as the iliac artery is not neointima but stent thrombosis.

Angiology, Vol. 50, No. 12, 977-987 (1999)
DOI: 10.1177/000331979905001203


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