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A Retrospective Study of Late Outcome in Patients with Peripheral Arterial Occlusive Disease: An Association Between Prosthetic Vascular Graft and Cancer Death?

Shunichi Kojima, MD

Takuya Umemoto, MD

Yasuo Hosoi, MD

Morio Kuramochi, MD

Yuji Yoshitomi, MD

Division of Cardiology Tohsei National Hospital 762-1, Nagasawa Shimizu-cho, Suntoh-gun Shizuoka 411 Japan

The authors assessed the relationship between cause of death and treatment modality in patients with peripheral arterial occlusive disease. A total of 273 patients were treated with percutaneous transluminal angioplasty, surgical reconstruction, amputation, or medical therapy. We evaluated the outcome in various patient subgroups divided by treatments with a mean follow-up of 4.9 years. Most patients died because of cardio vascular or cerebrovascular events, and cancer was the second most frequent cause of death. Furthermore, there was a significant difference in cancer deaths between patients who received prosthetic vascular grafts and those with other types of treatment (9.3% vs. 2.8%, p < 0.01, odds ratio = 3.34). It is noteworthy that patients with peripheral arterial occlusive disease succumbed to cancer, especially the patients with prosthetic vascular grafts.

Angiology, Vol. 50, No. 12, 1007-1015 (1999)
DOI: 10.1177/000331979905001206


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