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Angiology, Vol. 50, No. 1, 37-45 (1999)
DOI: 10.1177/000331979905000105

Early Detection of Anthracycline-Induced Cardiotoxicity by Radionuclide Angiocardiography

Jun Suzuki

Second Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan

Atsuo Yanagisawa

Second Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan

Toshiki Shigeyama

Second Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan

Jun Tsubota

Second Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan

Toshiaki Yasumura

Second Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan

Katsuya Shimoyama

Second Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan

Kyozo Ishikawa

Second Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan

For the early detection of myocardial damage associated with anthracycline therapy, electrocardiography, echocardiography, and radionuclide angiocardiography were used to assess cardiac function in 37 patients receiving anthracyclines (ie, adriamycin and daunorubicin at a total dose of 100-2,030 mg/m2). None of the patients developed clinical congestive heart failure. There were no significant changes of electrocardio graphic and echocardiographic parameters after anthracycline administration. The left ventricular ejection fraction did not change significantly on radionuclide angiocardiog raphy. However, the 1/3 peak filling rate (PFR) corrected by the end-diastolic count (EDC) (1/3 PFR/EDC) and the 1/3 filling fraction (1/3 FF), the indices of early diastolic function, showed a significant decrease. These findings suggest that the 1/3 PFR/EDC and 1/3 FF determined by radionuclide imaging are useful for detecting silent myocardial damage induced by anthracyclines.


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