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Effects of Picotamide on Release of Endothelin-1, Thromboxane, and Prostacycline After Treadmill Stress in Patients with Peripheral Artery Disease

Adriana Sardo, MD

Michele Bonaiuto, MD

Giuseppe Giordano, MD

Egidio Imbalzano, MD

Maria Castaldo, MD

Maurizio Cinquegrani, MD

Daniele D'Arrigo, MD

Giuseppe M. Campo, PhD

Francesco Squadrito, MD

To assess the effects of picotamide, an antithromboxane receptor and antithromboxane synthase drug, on vascular function and endothelin-1 release, 20 patients with peripheral arterial disease, without hypertension or diabetes mellitus, receiving placebo and pico tamide (900 mg/day) were studied. The modifications of vascular parameters were evaluated by arterial distensibility index and postischemic hyperemia test (postischemic perfusion index and recovery time). Endothelin-1, prostacycline, and thromboxane B₂ were determined under resting conditions and after treadmill test. Picotamide treatment caused a decrease of resting thromboxane B₂ and endothelin-1 concentrations, produced an improvement of the vascular function as seen by the increase of vascular parameters reported, and attenuated the ischemic treadmill-induced increase of thromboxane B ₂, but not of endothelin-1. These data confirm that the picotamide improved vascular flow by the reduction of thromboxane-mediated effects, reduced resting endothelin-1 levels, but did not attenuate endothelin-1 concentrations induced by the treadmill stress.

Angiology, Vol. 49, No. 11, 879-884 (1998)
DOI: 10.1177/000331979804901102


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