This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Kato, H. Articles by Kato, H. Search for Related Content PubMed PubMed Citation Articles by Kato, H. Articles by Kato, H. Social Bookmarking                         What's this?

The Antiatherogenic Effect of Nifedipine on Intramural Small Coronary Arterial Lesions in Cholesterol-Fed Rabbits

Ryuuichirou Okada

Masafumi Enoki

Kazuhisa Oogushi

Sei Emura

Toshinobu Takashima

Keizo Ohmori

Hiroyuki Kato, MD, PhD

Department of Internal Medicine Saga Medical School Nabeshima, Saga 849, Japan

The objective of this study was to examine the suppressive effect of nifedipine on intra mural coronary arterial lesions in cholesterol-fed rabbits. Each rabbit in Groups A (n=6) and B (n=5) was fed a 0.3% cholesterol diet and was orally administered nifedipine (40 mg/day) or placebo. Each rabbit in Groups C (n=5) and D (n=6) was fed a 0.5% choles terol diet and was orally administered nifedipine (40 mg/day) or placebo. The serum concentrations of total cholesterol (TC) were determined at 1-week intervals to calculate the integrated values. The lesion induction ratio was defined as the ratio of intramural coronary arteries 50-150 µm in diameter with arterial lipoidosis to the total number of arteries of the same diameter. There were no significant differences between the nifedipine-treated and placebo groups in either the integrated TC or lesion induction ratio in either the 0.3% and 0.5% cholesterol-fed rabbits. This study demonstrates that nifedipine does not suppress atherogenesis in the intramural small coronary arteries of cholesterol-fed rabbits.

Angiology, Vol. 49, No. 1, 49-54 (1998)
DOI: 10.1177/000331979804900106


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?