This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Kamishirado, H. Articles by Kamishirado, H. Search for Related Content PubMed PubMed Citation Articles by Kamishirado, H. Articles by Kamishirado, H. Social Bookmarking                         What's this?

Effect of Enalapril Maleate on Cerebral Blood Flow in Patients with Chronic Heart Failure

Teruo Inoue, MD, FACA

Tsuneo Fujito, MD

Makoto Kase, MD

Minoru Shimizu, MD

Yoshihiko Sakai, MD, FACA

Kan Takayanagi, MD, FACA

Shigenori Morooka, MD, FACA

Satoshi Natsui, RT

Hirotoshi Kamishirado, MD

Department of Cardiology, Koshigaya Hospital Dokkyo University School of Medicine 2-1-50 Minamikoshigaya, Koshigaya Saitama 343, Japan

The effect of enalapril on cerebral blood flow (CBF) was studied in 11 patients with chronic heart failure (NYHA II or III, dilated cardiomyopathy in 6 and old myocardial infarction in 5). CBF was evaluated by analyzing the Patlak-Plot curve obtained from radionuclide angiography with technetium-99m hexamethylpropylene amine oxime (^99mTc-HM-PAO). Cardiac index (CI) and stroke volume (SV) were simultaneously measured by impedance cardiography. These measurements were performed before and at four weeks after daily administration of 5 mg enalapril. The stroke volume, cardiac index, and heart rate were not significantly changed after four weeks of enalapril admin istration. However, CBF was increased by 6.5% from 36.72 ±4.66 to 39.13 ±5.65 mL/ 100g/min (P<0.05). These results suggest that enalapril increased cerebral blood flow, which was not related to increased cardiac output in congestive heart failure. Patlak-Plot analysis of radionuclide angiography using ^99m Tc-HM-PAO may be available for quantitative assessment of brain perfusion.

Angiology, Vol. 48, No. 8, 707-713 (1997)
DOI: 10.1177/000331979704800806


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?