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Angiology
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Venous Disease: From Pathophysiology to Quality of Life

P.M. Vanhoutte, MD, PhD

I.R.I.S. 6, Place des Plëiades 92415 Courbevoie Cedex France

S. Corcaud, MS, MBA

I.R.I.S. 6, Place des Plëiades 92415 Courbevoie Cedex France

C. de Montrion, PhD

I.R.I.S. 6, Place des Plëiades 92415 Courbevoie Cedex France

Paul M. Vanhoutte, MD, PhD

I.R.I.S. 6, Place des Plëiades 92415 Courbevoie Cedex France

Venous insufficiency is a multifactorial pathology that has an important impact on the quality of life of the patients. The primary factor of venous disease is an abnormal wall distensibility, which seems to be correlated with genetic factors. Facilitating factors include hormonal impregnation and prolonged hydrostatic load, particularly under condi tions where the control of the sympathetic nervous system is reduced by an increase in local temperature. The resulting valvular incompetence, combined with the augmented hydrostatic load, leads to varicosis and venous stasis. The ensuing tissue hypoxia and local edema favor inflammation and infection, which ultimately favor the occurrence of ulcers. The available data on the impact of the disease suggest a relation between the physiopathological phenomena and some parameters of health-related quality of life.

Angiology, Vol. 48, No. 7, 559-567 (1997)
DOI: 10.1177/000331979704800702


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This article has been cited by other articles:


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ANGIOLOGYHome page
P. Sansilvestri-Morel, A. Rupin, C. Badier-Commander, J.-N. Fabiani, and T. J. Verbeuren
Chronic Venous Insufficiency: Dysregulation of Collagen Synthesis
Angiology, July 1, 2003; 54(1_suppl): S13 - S18.
[Abstract] [PDF]



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