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Effects of Nisoldipine on Cytosolic Calcium, Platelet Aggregation, and Coagulation/Fibrinolysis in Patients with Coronary Artery Disease

Kazuo Takahara, MD

Chizuko Ohba, BS

Yasuhide Nakashima, MD

Akio Kuroiwa, MD

Kazuo Takahara, MD

The 2nd Department of Internal Medicine, School of Medicine University of Occupational and Environmental Health 1-1 Iseigaoka, Yahatanisi-ku Kitakyushu, 807 Japan

The effect of nisoldipine, a dihydropyridine Ca²⁺ antagonist, on the platelet cytosolic Ca ²⁺ concentration ( [Ca²⁺] i), platelet aggregation, and various coagulation and fibri nolysis parameters was assessed in normotensive patients with coronary artery disease (CAD). Eleven patients with angiographically confirmed CAD (4 men, 7 women aged 67.3 ±5.4 years) were administered nisoldipine at 10 mg/day for two weeks. The [Ca²⁺]i was determined by use of fura2-loaded platelets, platelet aggregation was measured with an aggregometer, and coagulation/fibrinolysis parameters were measured by standard methods. Nisoldipine did not significantly affect blood pressure or heart rate. However, the [Ca²⁺] decreased significantly (P<0.05) and platelet aggregation was also signifi cantly inhibited. Plasma D-dimer levels decreased significantly (P<0.01). Thus, nisol dipine not only suppressed platelet activation but also affected the coagulation system, suggesting that it is not only a vasodilator and platelet inhibitor but also an antithrom botic agent.

Angiology, Vol. 48, No. 6, 515-521 (1997)
DOI: 10.1177/000331979704800606


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