This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Sigounas, G. Articles by Sigounas, G. Search for Related Content PubMed PubMed Citation Articles by Sigounas, G. Articles by Sigounas, G. Pubmed/NCBI databases Substance via MeSH Social Bookmarking                         What's this?

Synergism of Hemopoietic Growth Factors on Endothelial Cell Proliferation

Manfred Steiner, MD, PhD

Athanasius Anagnostou, MD

George Sigounas, PhD

East Carolina University School of Medicine Department of Medicine Hematology/Oncology Division Brody Bldg, Rm 3E-127 Greenville, NC 27858

Endothelial cells, which are nonhemopoietic cells, express and/or produce most of the known hemopoietic receptors and cytokines. The biological role of these factors, and their respective receptors, on endothelial cells is still unknown. In this study, the authors assessed the effect of different hemopoietic growth factors, ie, interleukin-3 (IL-3), erythropoietin (EPO), macrophage-colony stimulating factor (M-CSF), granulocyte-colony stimulating factor (G-CSF), granulocyte macrophage-colony stimulating factor (GM-CSF), singly or in conjunction with others, on proliferation and chemotaxis of human umbilical vein endothelial cells (HUVECs). They found growth stimulatory activity with IL-3, EPO, and GM-CSF and potent synergism between EPO and IL-3, less with IL-3 and GM-CSF, and none with EPO and either GM-CSF or G-CSF. All the singly tested hemopoietic growth factors stimulated the migration of HUVECs, but in conjunction with other factors, they did not show any additive or synergistic effect.

Angiology, Vol. 48, No. 2, 141-147 (1997)
DOI: 10.1177/000331979704800207


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?