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Use of a Collagen Plug Versus Manual Compression for Sealing Arterial Puncture Site After Cardiac Catheterization

Reinhold Katzenschlager, MD

Gottfried Heinz, MD

Michael Gottsauner-Wolf, MD

Peter Probst, MD

Marianne Gwechenberger, MD

Department of Cardiology University of Vienna Währinger Gürtel 18-20 1090 Vienna, Austria

The aim of the study was to investigate (1) the safety and efficacy of the application of a collagen plug (Vasoseal®) at arterial puncture sites, (2) the hemostasis time, and (3) the comfort for the patient of a collagen plug (Vasoseal®) when compared with manual compression. Sixty-two patients were randomized either for application of a collagen plug (Vasoseal®, group A, n=33) or manual compression (group B, n=29) after cardiac catheterization. All patients were evaluated for subjective pain score ranging from 1 to 5 (1= no pain up to 5 =very strong pain). In addition the authors measured the time until hemostasis could be achieved. The patients were evaluated by duplex sonography for complications at days 1 and 7 after the procedure. The pain score demonstrated a signif icantly lower score in group A when compared with group B (P=0.01). The mean time for hemostasis was significantly lower in group A (mean 9.6 minutes) when compared with group B (mean 23.6 minutes) (P=0.0001). Regarding the complication rate there was no significant difference between the groups (group A vs group B, P=0.82). The authors conclude that the application of a collagen plug at the arterial puncture site is a safe and time-saving method. In addition it is less painful and therefore better tolerated than manual compression.

Angiology, Vol. 48, No. 2, 121-126 (1997)
DOI: 10.1177/000331979704800204


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